ESPERION THERAPEUTICS INC NE COMMON 29664W105 14485 289000 SH DFND 1 0 0 289000 ESPERION THERAPEUTICS INC NE COMMON 29664W105 5 100 SH DFND 0 0 100 MACROGENICS INC. COMMON 556099109 2142 115914 SH DFND 1 0 0 115914 MEDICINES CO COMMON 584688105 113183 3055689 SH DFND 1 0 0 3055689 MEDICINES CO COMMON 584688105 28825 778210 SH DFND 0 0 778210 MEDICINES CO COMMON 584688105 4 100 SH DFND 0 0 100 MIRATI THERAPEUTICS INC COMMON 60468T105 33704 2880702 SH DFND 1 0 0 2880702