SCHEDULE 13G/A 0000902664-25-003208 0001603466 XXXXXXXX LIVE 1 Common Stock, par value $0.0001 per share 12/31/2025 0001526119 Verastem, Inc. 92337C203 117 KENDRICK STREET SUITE 500 NEEDHAM MA 02494 Rule 13d-1(c) Point72 Asset Management, L.P. b DE 0.00 995026.00 0.00 995026.00 995026.00 N 1.3 PN Point72 Capital Advisors, Inc. b DE 0.00 995026.00 0.00 995026.00 995026.00 N 1.3 CO Steven A. Cohen b X1 0.00 995026.00 0.00 995026.00 995026.00 N 1.3 IN Verastem, Inc. 117 Kendrick Street, Suite 500, Needham, MA 02494 This statement is filed by: (i) Point72 Asset Management, L.P. ("Point72 Asset Management") with respect to the shares of common stock, par value $0.0001 per share ("Shares"), of Verastem, Inc. (the "Issuer") held by an investment fund it manages; (ii) Point72 Capital Advisors, Inc. ("Point72 Capital Advisors Inc.") with respect to the Shares held by an investment fund managed by Point72 Asset Management; and (iii) Steven A. Cohen ("Mr. Cohen") with respect to the Shares beneficially owned by Point72 Asset Management and Point72 Capital Advisors Inc. Each of Cubist Systematic Strategies, LLC and Point72 Europe (London) LLP are relying advisers on the Form ADV of Point72 Asset Management and each acts as a sub-advisor with respect to a portion of the Shares reported herein. The address of the principal business office of Point72 Asset Management, Point72 Capital Advisors Inc., and Mr. Cohen is 72 Cummings Point Road, Stamford, CT 06902. Point72 Asset Management is a Delaware limited partnership. Point72 Capital Advisors Inc. is a Delaware corporation. Mr. Cohen is a United States citizen. Y The information required by Item 4(a) is set forth in Row 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on December 31, 2025. Point72 Asset Management, Point72 Capital Advisors Inc., and Mr. Cohen own directly no Shares. Pursuant to an investment management agreement, Point72 Asset Management maintains investment and voting power with respect to the securities held by an investment fund it manages. Point72 Capital Advisors Inc. is the general partner of Point72 Asset Management. Mr. Cohen controls each of Point72 Asset Management and Point72 Capital Advisors Inc. The filing of this statement should not be construed as an admission that any of the foregoing persons or any Reporting Person is, for the purposes of Section 13 of the Securities Exchange Act of 1934, the beneficial owner of the Shares reported herein. The aggregate percentage of Shares reported to be beneficially owned by each Reporting Person is based on 77,181,869 Shares outstanding, which is the sum of (i) 8,543,794 Shares issued in the offering described in the Issuer's Prospectus filed pursuant to Rule 424(b)(5) with the Securities and Exchange Commission (the "SEC") on November 17, 2025; (ii) 1,862,069 Shares issued pursuant to the exercise of the underwriters' overallotment option as reported in the Issuer's Current Report on Form 8-K filed with the SEC on November 17, 2025; and (iii) 66,776,006 Shares outstanding as of November 3, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2025, filed with the SEC on November 4, 2025. 1.3% The information required by Item 4(c)(i) is set forth in Row 5 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on December 31, 2025. The information required by Item 4(c)(ii) is set forth in Row 6 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on December 31, 2025. The information required by Item 4(c)(iii) is set forth in Row 7 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on December 31, 2025. The information required by Item 4(c)(iv) is set forth in Row 8 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on December 31, 2025. N Y N See Item 2(a). Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Point72 Asset Management, L.P. /s/ Jason M. Colombo 02/17/2026 Point72 Capital Advisors, Inc. /s/ Jason M. Colombo 02/17/2026 Steven A. Cohen /s/ Jason M. Colombo 02/17/2026