The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE

OMB APPROVAL
OMB Number:3235-0006
Expires:Oct 31, 2018
Estimated average burden
hours per response:23.8

Report for the Calendar Year or Quarter Ended:12-31-2020
Check here if Amendment  Amendment Number:
This Amendment (Check only one.):  is a restatement.
  adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name:Cubist Systematic Strategies, LLC
Address:72 CUMMINGS POINT ROAD
STAMFORD, CT  06902
Form 13F File Number:028-16258

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:
Name:Jason M. Colombo
Title:Authorized Person
Phone:203-890-2000
Signature, Place, and Date of Signing:
/s/ Jason M. ColomboStamfordCT02-16-2021
[Signature][City, State][Date]
The Reporting Manager, Cubist Systematic Strategies, LLC, is under common control with Point72 Asset Management, L.P. (Form 13F File Number 028-16256), Point72 Hong Kong Ltd (Form 13F File Number 028-16027), Point72 Europe (London) LLP (Form 13F File Number 028-17887), 72 Investment Holdings, LLC (Form 13F File Number 028-20409), and CPV Partners, LLC (Form 13F File Number 028-19347). * Positions that are exempt from reporting under Special Instruction 10 to the Form 13F are excluded from this report. However, positions that would not be exempt when aggregated with positions of the same security held by (i) the Other Included Managers or (ii) certain affiliates of the Reporting Manager and reported on their own Forms 13F, are listed herein.
Report Type (Check only one.):
X13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)
  13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)
  13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)
Form 13F Summary Page
Report Summary:
Number of Other Included Managers:1
Form 13F Information Table Entry Total:2,537
Form 13F Information Table Value Total:7,273,018
(thousands)
Confidential information has been omitted from the public Form 13F report and filed separately with the U.S. Securities and Exchange Commission.
List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]
No.Form 13F File NumberName
1028-16256Point72 Asset Management, L.P.