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        <confirmingCopyFlag>false</confirmingCopyFlag>
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      <filer>
        <credentials>
          <cik>0001603465</cik>
          <ccc>XXXXXXXX</ccc>
        </credentials>
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      <periodOfReport>09-30-2025</periodOfReport>
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    <coverPage>
      <reportCalendarOrQuarter>09-30-2025</reportCalendarOrQuarter>
      <isAmendment>false</isAmendment>
      <filingManager>
        <name>Cubist Systematic Strategies, LLC</name>
        <address>
          <ns1:street1>72 Cummings Point Road</ns1:street1>
          <ns1:city>Stamford</ns1:city>
          <ns1:stateOrCountry>CT</ns1:stateOrCountry>
          <ns1:zipCode>06902</ns1:zipCode>
        </address>
      </filingManager>
      <reportType>13F HOLDINGS REPORT</reportType>
      <form13FFileNumber>028-16258</form13FFileNumber>
      <crdNumber>000292081</crdNumber>
      <provideInfoForInstruction5>Y</provideInfoForInstruction5>
      <additionalInformation>The Reporting Manager, Cubist Systematic Strategies, LLC, is under common control with Point72 Asset Management, L.P. (Form 13F File Number 028-16256), 72 Investment Holdings, LLC (Form 13F File Number 028-20409), Point72 Hong Kong Ltd (Form 13F File Number 028-16027), Point72 Europe (London) LLP (Form 13F File Number 028-17887), Point72 Italy, S.r.l. (Form 13F File Number 028-23927), Point72 Middle East FZE (Form 13F File Number 028-23094), Point72 (DIFC) Ltd. (Form 13F File Number 028-24178), CPV Partners, LLC (Form 13F File Number 028-19347), and Point72 Asia (Singapore) Pte. Ltd. (Form 13F File Number 028-17282). * Positions that are exempt from reporting under Special Instruction 10 to the Form 13F are excluded from this report. However, positions that would not be exempt when aggregated with positions of the same security held by (i) the Other Included Managers or (ii) certain affiliates of the Reporting Manager and reported on their own Forms 13F, are listed herein.</additionalInformation>
    </coverPage>
    <signatureBlock>
      <name>Jason M. Colombo</name>
      <title>Authorized Person</title>
      <phone>203-890-2000</phone>
      <signature>/s/ Jason M. Colombo</signature>
      <city>Stamford</city>
      <stateOrCountry>CT</stateOrCountry>
      <signatureDate>11-14-2025</signatureDate>
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      <tableEntryTotal>2948</tableEntryTotal>
      <tableValueTotal>20992806237</tableValueTotal>
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            <form13FFileNumber>028-16256</form13FFileNumber>
            <crdNumber>000283077</crdNumber>
            <secFileNumber>801-107348</secFileNumber>
            <name>Point72 Asset Management, L.P.</name>
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