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Research and Development Expense (Tables)
 12 Months Ended
Dec. 31, 2017
Research and Development Expense/General and Administrative Expense/Finance Income and Finance Expense [Abstract]  
Components of research and development expense

 

   

December 31,

2017

    

December 31,

2016

    

December 31,

2015

  
Pre-clinical projects     642,821       546,429       468,326  
Clinical projects     12,365,768       16,639,304       20,808,025  
Drug manufacturing and substance     2,027,184       2,608,814       1,866,148  
Employee benefits and expenses     2,773,516       2,854,624       2,140,664  
Lease expenses     111,680       84,344       42,953  
Patents and trademarks     603,892       941,836       824,201  
Regulatory projects     632,387       1,043,287       331,822  
Depreciation tangible assets     53,594       58,125       54,037  
Total research and development expense     19,210,842       24,776,763       26,536,176