6-K

UNITED STATES 

SECURITIES AND EXCHANGE COMMISSION  

Washington, D.C. 20549

FORM 6-K

REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934

For the month of January, 2018

Commission File Number: 001-36582 

Auris Medical Holding AG 

(Exact name of registrant as specified in its charter)

Bahnhofstrasse 21 

6300 Zug, Switzerland 

(Address of principal executive office)

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F:

 Form 20-F  X Form 40-F

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):

Yes No  X

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7):

Yes No  X

EXHIBIT INDEX

Exhibit Number	Description
99.1	Corporate Presentation, January 2018
99.2	Press Release dated January 29, 2018

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

Auris Medical Holding AG
By:	/s/ Hernan Levett
	Name:	Hernan Levett
	Title:	Chief Financial Officer

Date: January 29, 2018

EX-99.1

EXHIBIT 99.1

Corporate Presentation January 2018 NASDAQ: EARS Innovative Treatments for Inner Ear Disorders

1 Forward - looking Statements This presentation and the accompanying oral commentary contain “forward - looking” statements that involve substantial risks and uncertainties. All statements other than statements of historical facts contained in this presentation and the accompanying o ral commentary, including statements regarding our future financial condition, business strategy and plans and objectives of management for future operations, are forward - looking statements. In some cases, you can identify forward - looking statements by terminology such as “believe,” “will,” “may,” “estimate,” “continue,” “anticipate,” “intend,” “should,” “plan,” “might,” “app rox imately,” “expect,” “predict,” “could,” “potentially” or the negative of these terms or other similar expressions. Forward - looking stateme nts appear in a number of places throughout this presentation and the accompanying oral commentary and include statements regardi ng our intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things, our ongoing a nd planned preclinical development and clinical trials, the timing of and our ability to make regulatory filings and obtain and mai ntain regulatory approvals for our product candidates AM - 101 and AM - 111, our intellectual property position, our ability to develop commercial functions, expectations regarding clinical trial data, our results of operations, cash needs, financial condition, li quidity, prospects, growth and strategies, the industry in which we operate and the trends that may affect the industry or us. Forward - looking statements involve known and unknown risks, uncertainties, assumptions and other factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward - looking statements. These include, but are not limited to, the timing and conduct of clinica l trials of our product candidates, the clinical utility of our product candidates, including the likelihood that the TACTT3 trial may no t meet its endpoints, the timing or likelihood of regulatory filings and approvals, the timing or likelihood of regulatory filings and a ppr ovals, our intellectual property position and our financial position, including the impact of any future acquisitions, dispositions, par tne rships, license transactions or changes to our capital structure, including future securities offerings. These risks and uncertainties also include, but are not limited to, those described under the caption “Risk Factors” in our Annual Report on Form 20 - F and in futur e filings with the Securities and Exchange Commission. Forward - looking statements represent our management’s beliefs and assumptions only as of the date of this presentation. Except as required by law, we assume no obligation to update these forw ard - looking statements publicly, or to update the reasons why actual results could differ materially from those anticipated in th e f orward - looking statements, even if new information becomes available in the future. www.aurismedical.com | NASDAQ: EARS

Key Investment Highlights 2 www.aurismedical.com | NASDAQ: EARS Keyzilen ® for Acute Inner Ear Tinnitus: fast track designation Expect Phase 3 results in Q1 2018 3 Addressing the “Big 3” neurotology disorders with targeted - delivery products Hearing loss, Tinnitus and V ertigo 1 AM - 111 for Acute Inner Ear Hearing Loss: orphan & fast track designation Efficacy in Phase 3 subpopulation 2 High margin products with $3 billion global market potential 5 AM - 125 for Vertigo: reformulated betahistine Expect to initiate second Phase 1 trial in Q1 2018 4

3 Dedicated to Developing Neurotologic Therapeutics • Headquartered in Switzerland • Founded in 2003 • IPO in August 2014 • NASDAQ: EARS • Shares outstanding: 48.7M • Market cap: ~ $25M www.aurismedical.com | NASDAQ: EARS

Leadership Team Brings Significant Industry Experience Thomas Meyer, PhD Founder, Chairman and CEO • Former CEO and BoD member of diabetes care company Disetronic , >3B CHF market cap • Instrumental in Disetronic’s IPO and managing >20% sales CAGR over many years Hernan Levett , CPA Chief Financial Officer • Former Head of Group Controlling at Acino Pharma • Former VP of Finance Europe at InterMune • Former CFO of Novartis Chile 4 www.aurismedical.com | NASDAQ: EARS Andrea Braun, PhD Head, Regulatory and Quality Affairs • Former Head of Global Regulatory Affairs Biologics at Alvotech • Former Head of EU Regulatory Affairs at Roche

Robust Pipeline of Innovative Neurotologic Treatments 5 www.aurismedical.com | NASDAQ: EARS Dates of key milestones are indicative and subject to change.

6 Key Upcoming Milestones www.aurismedical.com | NASDAQ: EARS Q1 2018 • Announce TACTT3 top - line results • Start second AM - 125 Phase 1 trial Q2 2018 • Discussions on AM - 111 regulatory pathway • Complete AM - 125 Phase 1 trial • IND for AM - 125 Fall 2018 • Start AM - 125 Phase 2 trial

7 www.aurismedical.com | NASDAQ: EARS Keyzilen (AM - 101) for Tinnitus AM - 125 for Vertigo AM - 111 for Hearing Loss

Acute Inner Ear Tinnitus 8 • Unpleasant, unwanted sensation often perceived as “ringing” in the ears • Similar to pain sensation • Significant impact on sleep and ability to concentrate or relax • Substantial emotional distress and reduced quality of life • Acute stage = first three months • Current treatments: off - label steroids, ginkgo biloba, benzodiazepines, masking • 84% of US ENT physicians surveyed reported dissatisfaction with current tinnitus treatment options 1 www.aurismedical.com | NASDAQ: EARS Source: 1) Hall et al., Treatment options for subjective tinnitus: self reports from a sample of general practitioners and ENT physicians within Europe and the USA, 2011 “My world has come to a crashing halt. I can't study, I can't eat and I can't sleep. I am a skeleton of myself.”

Keyzilen Targets Aberrant NMDA Receptor Activity 9 www.aurismedical.com | NASDAQ: EARS • Noise overexposure causes acute injury of the inner ear • Keyzilen’s API, Esketamine , is a potent NMDA receptor antagonist • Inhibits aberrant NMDA mediated exitation of auditory nerve which is perceived as tinnitus following acute injury • Does not interfere with normal hearing • Administered 3 x over 3 - 5 days by intratympanic administration Cochlear I nner H air C ell S ynaptic C omplex

Proof of Concept in Two Phase 2 Trials 10 www.aurismedical.com | NASDAQ: EARS • Gradual and statistically significant improvement in tinnitus loudness (TLQ) and other PROs: • Tinnitus annoyance • Sleep difficulties • Tinnitus impact • Patients treated within first three months from tinnitus onset (= acute) • Treatment well tolerated • FDA Special Protocol Assessment for Phase 3: • Confirm clinical meaningfulness of effect in tinnitus loudness with statistically significant reduction in tinnitus impact • Impact measured by Tinnitus Functional Index (TFI) • Higher frequency of TLQ ratings Mean absolute improvement of subjective TLQ in patients with unilateral tinnitus following acute acoustic trauma or otitis media (n   =   84). TLQ was rated on a scale from 0 (no tinnitus heard) to 100 (extremely loud ). Van de Heyning et al., 2014. Phase 2 Data

11 • TACTT2 trial did not meet co - primary endpoints: change in TLQ and TFI • Potential design issue related to daily TLQ (patients focusing more on tinnitus, rating fatigue) • TFI performing better than TLQ • Clinically meaningful TFI improvement in relevant subgroups of patients with otitis media - related tinnitus • Keyzilen and intratympanic injection procedure well tolerated • Open label trials AMPACT1 and AMPACT2 • confirming good safety profile even with treatment for up to 12 months • suggesting potential benefits of repeating treatment cycles • supporting early treatment from onset of inner ear tinnitus www.aurismedical.com | NASDAQ: EARS First Phase 3 Not Meeting Expectations , But… 0 2 4 6 8 10 12 14 16 AM-101 0.87 mg/mL Placebo Reduction in TFI score Otitis media related tinnitus subpopulation Clinically meaningful p =0.048 Improvement of TFI score from baseline to Day 84 in patients with tinnitus related to otitis media ; repeated mesures ANCOVA (valid for efficacy population ; n=46).

Heading Into TACTT3 Read - Out 12 Applying key learnings from TACTT2 to its European sister trial TACTT3 • Protocol amendment in 2016 while still fully blinded • Elevated change in TFI to single primary efficacy endpoint • Enhanced statistical power by enrolling additional patients in each stratum • Included otitis media subgroup in confirmatory testing • Application of Hochberg testing procedure to control for multiplicity • Reduced TLQ rating frequency • Otitis media accounting for 37% of patients in TACTT3 compared to 16% in TACTT2 • TACTT3 t op - line results expected in Q1 2018 www.aurismedical.com | NASDAQ: EARS Change in TFI from baseline to Day 84 Overall population Otitis media tinnitus subpopulation Test first group with higher p - value against 0.05 significance value If < 0.05: both groups are significant If > 0.05: test other group against 0.025 TACTT3 Testing Strategy

Keyzilen: $750 Million US Market Potential 13 www.aurismedical.com | NASDAQ: EARS  53 US ENT doctors surveyed 1 • 41 general ENTs, 12 otologists  See an average of 44 tinnitus patients per month  Target label: acute peripheral tinnitus following traumatic injury to the cochlea or otitis media • Primary Market Research • Market Potential 38% tinnitus patients seeking treatment in acute stage (up to three months from onset) 74% of respondents expect monthly tinnitus patient volume to increase if an approved IT treatment were available 43% of their tinnitus patients considered candidates for Keyzilen type product 1) Survey conducted by MEDACorp, Inc. in April 2014 ~25% tinnitus cases caused by traumatic injury or otitis media 30% bilateral patients (both ears affected) ~250,000 treatable ears per year ~$750 Million market potential Upside Potential:  Other onset factors  Extension of window beyond three months  GP awareness driving increased referrals

14 www.aurismedical.com | NASDAQ: EARS Keyzilen (AM - 101) for Tinnitus AM - 125 for Vertigo AM - 111 for Hearing Loss

15 About Vertigo • False sensation of movement • Perceived as spinning or wheeling sensation • Potential for imbalance, nausea or vomiting • Peripheral causes include: • Functional: Meniere’s disease, labyrinthitis • Neurosensory : vestibular neuritis • Mechanical: benign paroxysmal positional vertigo (BPPV) • Tumors: vestibular schwannoma: intracranial tumor • Imbalance in signaling between left and right vestibular systems • Normally, left and right vestibular organs generate equal resting - state firing rates of action potentials, transmitting position and acceleration information to the brain • When a pathology disrupts signaling unilaterally, imbalance in vestibular tone can lead to illusory perception of movement www.aurismedical.com | NASDAQ: EARS

16 Betahistine Targets Histamine Receptors • Betahistine is a histamine analogue • H 1 receptor agonist • H 3 receptor antagonist • Both receptors widely expressed in brain and inner ear • Betahistine is used to treat vertigo by increasing • cochlear and vestibular blood flow ( peripheral ) • metabolism in vestibular neurons (central) • Oral betahistine is rapidly metabolized and has low bioavailability (~1%) • AM - 125 is being developed for intranasal administration of betahistine • Markedly higher plasma concentrations in Phase 1 • Second Phase 1 planned for Q1/Q2 2018 • Phase 2 planned to start in late 2018 www.aurismedical.com | NASDAQ: EARS 1 4 14 28 71 0 10 20 30 40 50 60 70 80 Relative to C max oral administration C max Betahistine in Plasma Oral Intranasal Single - dose Phase 1 study with intranasal delivery in healthy volunteers showed dose - dependent betahistine concentration in blood plasma with T max about 10 minutes post - dose, suggesting rapid onset , and significantly higher plasma concentrations C max than with oral dosing

17 AM - 125 Market Opportunity • ~35% of US adults over 40 years old (69 million Americans) have experienced some form of vestibular dysfunction 1 • Almost 4 million ER visits p.a. related to dizziness or vertigo 2 • Oral betahistine is one of the most widely - used medications for treating vertigo • Current worldwide annual betahistine sales total ~$450 million (at manufacturer prices ) • Not approved in the US, but supplies from compounding pharmacies and Canadian mail order pharmacies • Despite limited availability, 56% of US neurotologists and 16% of generalists use it 3 • 20 - 30% of neurotologists use it often or always • US market opportunity for AM - 125 estimated at $400 million www.aurismedical.com | NASDAQ: EARS 1 Agrawal et al . (2009), Arch Intern Med. 169(10 ): 938 - 44. 2 Saber Tehrani A et al. (2013), Acad Emerg Med. 20(7):689 - 96. 3 Clyde et al. (2017), Otol Neurotol 38(6):159 - 67.

18 www.aurismedical.com | NASDAQ: EARS Keyzilen (AM - 101) for Tinnitus AM - 125 for Vertigo AM - 111 for Hearing Loss

Acute Inner Ear Hearing Loss 19 • Loss of sound perception • Significant impact on cognitive and auditory function • Substantially reduced quality of life • Acute stage = first four weeks • Oral corticosteroids de facto standard of care despite lack of evidence for efficacy 1 • Poor prognosis for acute profound hearing loss www.aurismedical.com | NASDAQ: EARS Source: 1) Wei BP et al., Steroids for idiopathic sudden sensorinerual hearing loss, 2013, Stachler et al., Clinical practice guideline: sudden hearing loss, 2012. “None of the treatments were able to bring back my hearing to normal and I currently can only hear at 60 dB in my right ear with no word recognition.”

AM - 111 Protects Stress Injured Sensory Cells 20 • C - jun N - terminal Kinase (JNK) involved in various cochlear insults • Stress conditions and pro - inflammatory cytokines activate JNK • AM - 111 is a potent cell - penetrating JNK inhibitor peptide protecting against apoptosis and inflammation • Otoprotection demonstrated in various acute cochlear injury models, e.g. noise trauma, ischemia, infection, inflammation, surgery trauma • Administered by single dose intratympanic injection www.aurismedical.com | NASDAQ: EARS Outer hair cells Inner hair cells Treated with AM - 111 four hours post trauma Treated with placebo four hours post trauma AM - 111 prevents or attenuates hearing loss by protecting hair cell functionality

21 Significant Hearing Improvement in Phase 3 www.aurismedical.com | NASDAQ: EARS Profound acute hearing loss (≥ 90 dB) at baseline 0.018 0.016 0 5 10 15 20 25 30 35 40 45 50 Day 3 Day 7 Day 28 Day 91 AM-111 0.4 mg/mL AM-111 0.8 mg/mL Placebo Improvement of hearing threshold at the average of the three worst affected contiguous test frequencies from baseline ; post - hoc repeated mesures ANCOVA ( mITT ; n=98). 0.167 • HEALOS phase 3 trial did not meet primary efficacy endpoint in overall population • Active numerically superior to placebo at all time points , though • Statistically and clinically significant treatment effect in subpopulation of patients with profound acute sudden deafness • Supported by likewise improvement in speech discrimination • Significant reduction in risk of no improvement / chronification of profund hearing loss • Similar outcomes as in Phase 2 • Favorable safety profile confirmed

AM - 111: $400 Million US Market Potential 22 www.aurismedical.com | NASDAQ: EARS  53 US ENT doctors surveyed 1 • 41 general ENTs, 12 otologists  See an average of 11 patients with sudden deafness and 6 patients with acute acoustic trauma per month • Primary Market Research • Market Potential 40% patients seeking treatment within first three days 43% have severe to profound hearing loss 64% expect ASNHL patient volume to increase if an approved IT treatment were available 1) Survey by MEDACorp , Inc . 10% bilateral patients (both ears affected) ~50,000 treatable ears per year ~ $400 Million market potential Upside Potential:  Other onset factors  GP awareness driving increased referrals 60% of their ASNHL patients considered as candidates for AM - 111 type product  Target label: profound ASNHL – Sudden deafness / ISSNHL (>50% of potential) – Acute acoustic trauma (workplace accidents, military) – Surgery trauma (cochlea implants, stapes & mastoid surgery)

Key Strategy Elements 23 www.aurismedical.com | NASDAQ: EARS Emerge as first neurotology company to bring first - in - class products to market Retain rights in US & EU Selectively partner in Asia and other regions Build commercial organization to serve ENTs with highly synergistic products Expand portfolio with additional products for ENT indications

Financial Overview 24 www.aurismedical.com | NASDAQ: EARS • 2018 operating expenses estimated at CHF 18m • Decreasing over 2017 as phase 3 trials completed / completing • Only partly compensated by increasing spending on AM - 125 • Declining sequentially through 2018 • Funding with cash on hand up to Q2 2018, including net proceeds of Jan 2018 offering up to Q3 2018 • LPC equity line (USD 11.7m remaining) Key figures ( in CHF thousands) CHF 1,000 Operating expenses 2016 30,223 Operating expenses 2017 ( guidance ) 25,000 Cash and cash equivalents 30/9/2017 20,198 Debt 30/9/2017 amortized through Jan 2020 11,032

25 Ownership / Capitalization www.aurismedical.com | NASDAQ: EARS O WNE R S H IP T AB L E a s of Jan 23, 2018 Hold e r # of Com m on S h a re s % of Com m on S h a re s 5% Hol d e r s Sofinnova Venture 7,818,175 16.06 % Sofinnova Capital 5,384,450 11.06 % T o t al o w ne r s hip > 5 % 15,702,625 27 . 12 % All Di r ec t o r s a n d O f fi c e r s as a g r oup 7,302,042 15 . 00 % Other shareholders 28,169,223 57.87% Total common shares outstanding 48,673,890 100.0% C A PI T A L I Z A TION T AB L E a s of Jan 23, 2018 De sc r ipt i on C o mm on E qui v a l e n t Comm o n S h a r es O ut s t a n ding 48,673,890 O ptio n s ( w eig ht ed a v e r a g e price $ 1.74 ) 2,251,540 R e s tric t ed St o c k Uni t s 0 W ar r a nt s (weighted average price $1.25) 8,101,726 T o t al F u lly Dilu t ed S h a r es 59,027,156

26 Key Takeways www.aurismedical.com | NASDAQ: EARS Unmet medical need, serious conditions, safe treatments Targeting three major disorders: tinnitus, hearing loss and vertigo No FDA approved products Late stage pipeline Large US and global market opportunity in inner ear disorders Major news flow in 2018

Auris Medical Holding AG Bahnhofstrasse 21 CH - 6300 Zug Tel. +41 41 729 71 94 | Fax +41 61 201 13 51 www.aurismedical.com | NASDAQ: EARS Take care of your ears!

EX-99.2

EXHIBIT 99.2

Auris Medical Announces Pricing of $5.5 Million Registered Direct Offering

Zug, Switzerland, January 29, 2018 – Auris Medical Holding AG (“Auris Medical”, NASDAQ: EARS), a clinical-stage company dedicated to developing therapeutics that address important unmet medical needs in otolaryngology, today announced that it has entered into a securities purchase agreement with investors providing for the purchase and sale of 12,499,999 common shares at a price of $0.44 per share (payable in Swiss Francs) in a registered direct offering, resulting in total gross proceeds of approximately $5.5 million (or approximately CHF 5.1 million). The Company also agreed to issue warrants to purchase up to an aggregate of 7,499,999 common shares to the investors in a concurrent private placement. The warrants have an exercise price of $0.50 per share. The warrants will be exercisable immediately upon the closing date and will expire seven years from the date they become exercisable. The closing of the offering is expected to take place on or about January 30, 2018, subject to the satisfaction of customary closing conditions.

Ladenburg Thalmann & Co. Inc., a subsidiary of Ladenburg Thalmann Financial Services Inc. (NYSE American:LTS), is acting as exclusive placement agent for the registered direct offering and the concurrent private placement.

The common shares were offered pursuant to a shelf registration statement on Form F-3 (File No. 333-206710), which was declared effective by the United States Securities and Exchange Commission (“SEC”) on September 10, 2015. The warrants and shares issuable upon exercise of the warrants were offered in a concurrent private placement not registered under the Securities Act of 1933, as amended. Auris Medical has agreed to file a registration statement on Form F-1 with the SEC covering the resale of the common shares issuable upon exercise of the warrants.

This press release does not constitute an offer to sell or a solicitation of an offer to buy these securities, nor will there be any sale of these securities in any jurisdiction in which such offer solicitation or sale are unlawful prior to registration or qualification under securities laws of any such jurisdiction. A prospectus supplement relating to the common shares will be filed by Auris Medical with the SEC. When available, copies of the prospectus supplement, together with the accompanying prospectus, can be obtained at the SEC’s website at www.sec.gov or from Ladenburg Thalmann & Co. Inc., Attn: Syndicate Department, 277 Park Avenue, 26th Floor, New York, New York 10172 or by email at prospectus@ladenburg.com.

About Auris Medical

Auris Medical is a Swiss biopharmaceutical company dedicated to developing therapeutics that address important unmet medical needs in neurotology. The company is focused on the Phase 3 development of treatments for acute inner ear hearing loss (AM-111) and for acute inner ear tinnitus (Keyzilen^®; AM-101) by way of intratympanic administration with biocompatible gel formulations. In addition, Auris Medical is developing intranasal betahistine for the treatment of vertigo (AM-125) as well as early-stage research and development projects. The Company was founded in 2003 and is headquartered in Zug, Switzerland. The shares of Auris Medical Holding AG trade on the Nasdaq Capital Market under the symbol “EARS.”

Auris Medical Holding AG · Bahnhofstrasse 21 · CH-6300 Zug · Tel. +41 41 729 71 94 ·

Forward-looking Statements

This press release may contain statements that constitute “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward-looking statements are statements other than historical fact and may include statements that address future operating, financial or business performance or Auris Medical’s strategies or expectations. In some cases, you can identify these statements by forward-looking words such as “may,” “might,” “will,” “should,” “expects,” “plans,” “anticipates,” “believes,” “estimates,” “predicts,” “projects,” “potential,” “outlook” or “continue,” and other comparable terminology. Forward-looking statements are based on management’s current expectations and beliefs and involve significant risks and uncertainties that could cause actual results, developments and business decisions to differ materially from those contemplated by these statements. These risks and uncertainties include, but are not limited to, Auris Medical’s need for and ability to raise substantial additional funding to continue the development of its product candidates, the timing and conduct of clinical trials of Auris Medical’s product candidates, including the likelihood that the TACTT3 clinical trial with Keyzilen^® will not meet its endpoints, the clinical utility of Auris Medical’s product candidates, the timing or likelihood of regulatory filings and approvals, Auris Medical’s intellectual property position and Auris Medical’s financial position, including the impact of any future acquisitions, dispositions, partnerships, license transactions or changes to Auris Medical’s capital structure, including future securities offerings. These risks and uncertainties also include, but are not limited to, those described under the caption “Risk Factors” in Auris Medical’s Annual Report on Form 20-F and future filings with the Securities and Exchange Commission. Forward-looking statements speak only as of the date they are made, and Auris Medical does not undertake any obligation to update them in light of new information, future developments or otherwise, except as may be required under applicable law. All forward-looking statements are qualified in their entirety by this cautionary statement.

Company contact: Hernan Levett, Chief Financial Officer, +41-61-201-1350, hle@aurismedical.com

Investor contact: Daniel Ferry, LifeSci Advisors, LLC, +1-617-535-7746, investors@aurismedical.com

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