Stock-Based Compensation - Schedule of Share Option Activity (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended	12 Months Ended
	Mar. 31, 2022	Dec. 31, 2021
Number of Stock Options
Outstanding at beginning of period (in shares)	4,230,162
Options granted (in shares)	2,188,700
Options forfeited (in shares)	(391,106)
Options exercised (in shares)	0
Options expired (in shares)	(212,909)
Outstanding at end of period (in shares)	5,814,847	4,230,162
Options vested and exercisable (in shares)	2,554,368
Weighted Average Exercise Price
Outstanding at beginning of period (in dollars per share)	$ 8.92
Options granted (in dollars per share)	1.93
Options forfeited (in dollars per share)	11.14
Options exercised (in dollars per share)	0
Options expired (in dollars per share)	9.26
Outstanding at end of period (in dollars per share)	6.13	$ 8.92
Options vested and exercisable (in dollars per share)	$ 7.43
Stock Option Activity, Additional Disclosures
Options outstanding, weighted average remaining contractual life (in years)	8 years	8 years 4 months 24 days
Options vested and exercisable, weighted average remaining contractual life (in years)	6 years
Options outstanding, total intrinsic value	$ 406	$ 0
Options vested and exercisable, total intrinsic value	$ 0