Share-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2022

Share-Based Payment Arrangement [Abstract]

Schedule of Option Activity

The following table summarizes the number of stock options outstanding under the Plan for the years ended December 31, 2022.

	Number of Shares (in thousands)	Weighted-Average Exercise Price		Weighted-Average Remaining Contractual Life (in years)	Aggregate Intrinsic Value  (in thousands)
Outstanding at December 31, 2021	12,074	$	12.84	7.86	$	121,141
Granted	3,913	$	11.14
Exercised/released	(77)	$	6.55
Cancelled/forfeited	(2,615)	$	14.32
Outstanding at December 31, 2022	13,295	$	12.09	7.74	$	21
Options exercisable, December 31, 2022	8,345	$	11.94
Vested and expected to vest, December 31, 2022	12,884	$	11.98

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions

The following weighted average assumptions were used to estimate the fair value of the options granted during the years ended December 31, 2022, 2021 and 2020:

	2022		2021		2020
Expected term (in years)	5 years		4 years		3 years
Volatility	70	%	66	%	52	%
Risk-free interest rate	2.06	%	0.46	%	0.55	%
Dividend yield	0.0	%	0.0	%	0.0	%

Schedule of Un-vested Share Activity

The following table summarizes the PA and RSU activity for the year ended December 31, 2022:

	Number of Shares (in thousands)	Weighted-Average Grant Date Fair Value
Unvested balance, December 31, 2021	347	$	13.33
Granted	2,374	$	11.16
Vested	(305)	$	14.17
Forfeited	(436)	$	12.21
Unvested balance, December 31, 2022	1,980	$	10.84

Allocation of Share-Based Payments

Share-based compensation expense for the years ended December 31, 2022, 2021 and 2020 totaled approximately $32.3 million, $31.2 million and $17.5 million, respectively, as shown in the table below.

(in thousands)	2022		2021		2020
Research and development	$	3,271	$	4,442	$	3,730
Selling, general and administrative	28,438		26,432		13,615
Capitalized under inventories	591		369		109
Share-based compensation expense	$	32,300	$	31,243	$	17,454

Share-based Payment Arrangement, Nonvested Award, Cost

As of December 31, 2022, the unrecognized share-based cost, and the estimated weighted-average amortization period, using the straight-line attribution method, was as follows (in thousands, except amortization period):

	Unrecognized share-based compensation expense		Weighted average remaining amortization period (in years)
Stock Options	$	10,869	1.12
Restricted Stock Units	10,584		1.52
ESPP	1,327		0.52
Total unrecognized share-based compensation expense	$	22,780	1.30