CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
Cash flows used in operating activities:
Net loss	$ (51,145)	$ (82,134)
Adjustments to reconcile net loss to net cash used in operating activities
Depreciation and amortization	6,698	2,487
Net amortization of premiums and discounts on short-term investments	(8,836)	(14)
Share-based compensation expense	33,543	25,398
Write-down of inventory	916	2,464
Other, net	(3,910)	601
Net changes in operating assets and liabilities
Accounts receivable, net	(24,463)	(26,356)
Inventories, net	(8,984)	(8,458)
Prepaid expenses and other current assets	(2,889)	(3,461)
Non-current operating assets	(16)	(830)
Accounts payable, accrued and other liabilities	11,812	875
Operating lease liabilities	(499)	(551)
Net cash used in operating activities	(47,773)	(89,979)
Cash flows used in investing activities:
Purchase of investments	(379,213)	(403,184)
Proceeds from investments	391,287	346,109
Upfront lease payment	(11,864)	(381)
Purchase of long-lived assets	(419)	(158)
Capitalized patent costs	(240)	0
Net cash provided by (used in) investing activities	(449)	(57,614)
Cash flows from financing activities
Proceeds from exercise of stock options and employee share purchase plan	3,929	1,745
Finance lease payment	(3,482)	0
Cash provided by financing activities	447	1,745
Net decrease in cash, cash equivalents and restricted cash	(47,775)	(145,848)
Cash, cash equivalents and restricted cash, beginning of period	94,172	231,900
Cash, cash equivalents and restricted cash, end of period	46,397	86,052
Supplemental cash flow information
Cash received for interest	3,559	1,705
Cash paid for income taxes	(339)	(779)
Reconciliation of cash, cash equivalents and restricted cash to the condensed consolidated balance sheets
Cash, cash equivalents	45,557	85,341
Restricted cash	840	711
Total cash, cash equivalents and restricted cash	$ 46,397	$ 86,052