CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Cash flows used in operating activities:
Net loss	$ (37,698)	$ (73,145)
Adjustments to reconcile net loss to net cash used in operating activities
Depreciation and amortization	1,243	1,374
Amortization of right-of-use assets	193	304
Net amortization of premiums and discounts on short-term investments	(5,599)	351
Share-based compensation expense	21,735	17,078
Other, net	(3,235)	2,160
Net changes in operating assets and liabilities
Accounts receivable, net	(6,016)	(2,758)
Inventories, net	(8,403)	(7,953)
Prepaid expenses and other current assets	2,374	(4,914)
Non-current assets	(16)	(517)
Accounts payable, accrued and other liabilities	1,245	(6,242)
Operating lease liabilities	(319)	(355)
Net cash used in operating activities	(34,496)	(74,617)
Cash flows used in investing activities:
Purchase of investments	(256,439)	(232,955)
Proceeds from investments	288,291	225,677
Upfront lease payment	(11,864)	0
Purchase of long-lived assets	(524)	(118)
Capitalized patent costs	(212)	0
Net cash provided by (used in) investing activities	19,252	(7,396)
Cash flows from financing activities
Proceeds from exercise of stock options and employee share purchase plan	2,779	1,745
Cash provided by financing activities	2,779	1,745
Net decrease in cash, cash equivalents and restricted cash	(12,465)	(80,268)
Cash, cash equivalents and restricted cash, beginning of period	94,172	231,900
Cash, cash equivalents and restricted cash, end of period	81,707	151,632
Supplemental cash flow information
Cash received for interest	2,713	528
Cash paid for income taxes	(277)	(779)
Cash paid for amounts included in the measurement of lease liabilities	(531)	(572)
Finance right-of-use asset obtained in exchange for lease obligations (monoplant)	117,622	0
Finance lease liability arising from obtaining right-of-use assets (monoplant)	94,120	0
Reconciliation of cash, cash equivalents and restricted cash to the condensed consolidated balance sheets
Cash, cash equivalents	81,389	151,408
Restricted cash	318	224
Total cash, cash equivalents and restricted cash	$ 81,707	$ 151,632