The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 825 36,733 SH   SOLE   36,733 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 359 15,000 SH   SOLE   15,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 1,309 16,002 SH   SOLE   16,002 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 477 50,004 SH   SOLE   50,004 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 1,544 13,853 SH   SOLE   13,853 0 0
ALKERMES PLC SHS G01767105 1,410 24,333 SH   SOLE   24,333 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 1,629 13,680 SH   SOLE   13,680 0 0
AMGEN INC COM 031162100 990 5,805 SH   SOLE   5,805 0 0
AVEXIS INC COM 05366U100 281 2,275 SH   SOLE   2,275 0 0
AXSOME THERAPEUTICS INC COM 05464T104 327 133,500 SH   SOLE   133,500 0 0
BIO TECHNE CORP COM 09073M104 303 2,009 SH   SOLE   2,009 0 0
BIOGEN INC COM 09062X103 963 3,517 SH   SOLE   3,517 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 864 10,656 SH   SOLE   10,656 0 0
BLUEBIRD BIO INC COM 09609G100 226 1,326 SH   SOLE   1,326 0 0
CELGENE CORP COM 151020104 849 9,512 SH   SOLE   9,512 0 0
CHARLES RIV LABS INTL INC COM 159864107 279 2,613 SH   SOLE   2,613 0 0
CHECKPOINT THERAPEUTICS INC COM 162828107 495 112,760 SH   SOLE   112,760 0 0
CLOVIS ONCOLOGY INC COM 189464100 686 13,000 SH   SOLE   13,000 0 0
CONTRAFECT CORP COM 212326102 122 75,000 SH   SOLE   75,000 0 0
FIBROGEN INC COM 31572Q808 845 18,281 SH   SOLE   18,281 0 0
GILEAD SCIENCES INC COM 375558103 276 3,667 SH   SOLE   3,667 0 0
GRIFOLS S A SP ADR REP B NVT 398438408 285 13,422 SH   SOLE   13,422 0 0
ILLUMINA INC COM 452327109 1,302 5,506 SH   SOLE   5,506 0 0
INCYTE CORP COM 45337C102 940 11,278 SH   SOLE   11,278 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 277 4,496 SH   SOLE   4,496 0 0
INTREXON CORP COM 46122T102 283 18,478 SH   SOLE   18,478 0 0
IONIS PHARMACEUTICALS INC COM 462222100 1,020 23,133 SH   SOLE   23,133 0 0
IQVIA HLDGS INC COM 46266C105 283 2,889 SH   SOLE   2,889 0 0
ISHARES TR NASDAQ BIOTECH 464287556 2,001 18,750 SH   SOLE   18,750 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 671 50,000 SH   SOLE   50,000 0 0
LOXO ONCOLOGY INC COM 548862101 796 6,900 SH   SOLE   6,900 0 0
MEDICINES CO COM 584688105 231 7,000 SH   SOLE   7,000 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105 2,067 3,594 SH   SOLE   3,594 0 0
NEKTAR THERAPEUTICS COM 640268108 2,490 23,431 SH   SOLE   23,431 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 268 3,232 SH   SOLE   3,232 0 0
PACIRA PHARMACEUTICALS INC COM 695127100 389 12,500 SH   SOLE   12,500 0 0
PARATEK PHARMACEUTICALS INC COM 699374302 260 20,000 SH   SOLE   20,000 0 0
PROGENICS PHARMACEUTICALS IN COM 743187106 81 10,891 SH   SOLE   10,891 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 473 153,846 SH   SOLE   153,846 0 0
PROSHARES TR PSHS ULT NASB 74347R214 10,330 187,610 SH   SOLE   187,610 0 0
PROSHARES TR PSHS ULT NASB 74347R214 3,304 60,000 SH Put SOLE   60,000 0 0
QIAGEN NV SHS NEW N72482123 1,072 33,165 SH   SOLE   33,165 0 0
RECRO PHARMA INC COM 75629F109 139 12,615 SH   SOLE   12,615 0 0
REGENERON PHARMACEUTICALS COM 75886F107 903 2,622 SH   SOLE   2,622 0 0
SCYNEXIS INC COM 811292101 45 33,304 SH   SOLE   33,304 0 0
SEATTLE GENETICS INC COM 812578102 1,106 21,126 SH   SOLE   21,126 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 2,088 23,800 SH   SOLE   23,800 0 0
TESARO INC COM 881569107 657 11,500 SH   SOLE   11,500 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 372 7,291 SH   SOLE   7,291 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 290 2,579 SH   SOLE   2,579 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 1,503 9,224 SH   SOLE   9,224 0 0