SCHEDULE 13G/A 0001600136-25-000011 0001600136 XXXXXXXX LIVE 1 Common Stock, par value $0.01 per share 12/31/2025 0000818033 HERON THERAPEUTICS, INC. /DE/ 427746102 100 Regency Forest Drive Suite 300 Cary NC 27518 Rule 13d-1(b) Clearline Capital LP DE 0.00 12235239.00 0.00 12235239.00 12235239.00 6.7 IA PN Clearline Capital LLC DE 0.00 12235239.00 0.00 12235239.00 12235239.00 6.7 HC Marc Majzner X1 0.00 12235239.00 0.00 12235239.00 12235239.00 6.7 HC IN HERON THERAPEUTICS, INC. /DE/ 100 Regency Forest Drive, Suite 300, Cary, NORTH CAROLINA, 27518. Clearline Capital LP Clearline Capital LLC Marc Majzner Each a "Filer." The address for each Filer is 750 Lexington Avenue, 25th Floor, New York, NY 10022. See Item 4 of the cover page for each Filer. N IA HC See Item 9 of the cover page for each Filer. As of December 31, 2025, Clearline Capital LP may be deemed to beneficially own an aggregate of 12,235,239 shares of Common Stock, par value $0.01 per share (the "Common Stock"), of Heron Therapeutics, Inc. (the "Issuer"). Ownership percentages are based on 183,362,522 Common Stock reported as issued and outstanding as of October 30, 2025 in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 4, 2025. See Item 11 of the cover page for each Filer. See Item 5 of the cover page for each Filer. See Item 6 of the cover page for each Filer. See Item 7 of the cover page for each Filer. See Item 8 of the cover page for each Filer. Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. Exhibit 1: Joint Filing Agreement Clearline Capital LP Marc Majzner 02/17/2026 Clearline Capital LLC Marc Majzner 02/17/2026 Marc Majzner Marc Majzner 02/17/2026