X0306 4 2022-08-11 1 0001598646 Minerva Neurosciences, Inc. NERV 0000312069 BARCLAYS PLC 1 CHURCHILL PLACE CANARY WHARF LONDON X0 E14 5HP UNITED KINGDOM 0 0 1 0 a) The reporting persons did not engage in any reportable transactions during the relevant period. The reporting persons are no longer subject to Section 16 as a result of the unwind of certain stock borrow and repurchase transaction activity that did not create in the reporting persons, a pecuniary interest in the securities. b) Name of Person Filing: (1) Barclays PLC (2) Barclays Bank PLC (controlled by Barclays PLC) c) Address of Principal Business Office or, if none, Residence: (1) Barclays PLC 1 Churchill Place, London, E14 5HP, England (2) Barclays Bank PLC 1 Churchill Place, London, E14 5HP, England (3)Barclays Capital, Inc. 745 7th Avenue New York, New York 10019 United States Suejean Mott 2022-08-16