X0306 4 2021-04-27 0 0001445499 IMPEL NEUROPHARMA INC IMPL 0001674324 5AM Ventures V, L.P. 501 2ND STREET, SUITE 350 SAN FRANCISCO CA 94107 0 0 1 0 0001791889 5AM Partners V, LLC 501 2ND STREET, SUITE 350 SAN FRANCISCO CA 94107 0 0 1 0 0001664281 PARMAR KUSH 501 2ND STREET, SUITE 350 SAN FRANCISCO CA 94107 0 0 1 0 0001219014 ROCKLAGE SCOTT M 501 2ND STREET, SUITE 350 SAN FRANCISCO CA 94107 0 0 1 0 0001598549 Schwab Andrew J. 501 2ND STREET, SUITE 350 SAN FRANCISCO CA 94107 0 0 1 0 0001753000 5AM Opportunities I, L.P. 501 2ND STREET, SUITE 350 SAN FRANCISCO CA 94107 0 0 1 0 0001790778 5AM Opportunities I (GP), LLC 501 2ND STREET, SUITE 350 SAN FRANCISCO CA 94107 0 0 1 0 Common Stock 2021-04-27 4 C 0 808259 A 808259 I See footnote Common Stock 2021-04-27 4 C 0 540265 A 1348524 I See footnote Common Stock 2021-04-27 4 C 0 500932 A 1849456 I See footnote Common Stock 2021-04-27 4 C 0 358878 A 2208334 I See footnote Common Stock 2021-04-27 4 C 0 101457 13.50 A 2309791 I See footnote Common Stock 2021-04-27 4 P 0 575000 15.00 A 575000 I See footnote Series C-1 Preferred Stock 2021-04-27 4 C 0 13233885 0.00 D Common Stock 808259 0 I See Footnote Series C-2 Preferred Stock 2021-04-27 4 C 0 8845942 0.00 D Common Stock 540265 0 I See Footnote Series C-3 Preferred Stock 2021-04-27 4 C 0 8201930 0.00 D Common Stock 500932 0 I See Footnote Series D Preferred Stock 2021-04-27 4 C 0 5876034 0.00 D Common Stock 358878 0 I See Footnote 5% Convertible Note due 2021 13.50 2021-04-27 4 C 0 1359799.28 0.00 D 2021-12-31 Common Stock 101457 0 I See Footnote Each share Series C-1 Preferred Stock, Series C-2 Preferred Stock, Series C-3 Preferred Stock and Series D Preferred Stock automatically converted into shares of Common Stock upon the closing of the Issuer's initial public offering (the "IPO") for no additional consideration, on a 16.37332-for-one basis, and had no expiration date. The shares are directly held by 5AM Ventures V, L.P. ("Ventures V"). 5AM Partners V, LLC ("Partners V") is the sole general partner of Ventures V. Andrew J. Schwab, Dr. Scott M. Rocklage and Dr. Kush Parmar, are the managing members of Partners V and may be deemed to have shared voting and investment power over the shares beneficially owned by Ventures V. Each of Partners V, Mr. Schwab, Dr. Rocklage and Dr. Parmar disclaims beneficial ownership of such shares except to the extent of its or his pecuniary interest therein. The shares are directly held by 5AM Opportunities I, L.P ("Opportunities LP"). 5AM Opportunities I (GP), LLC ("Opportunities GP") is the sole general partner of Opportunities LP. Andrew J. Schwab and Dr. Kush Parmar are the managing members of Opportunities GP and may be deemed to have shared voting and investment power over the shares beneficially owned by Opportunities LP. Each of Opportunities GP, Mr. Schwab and Dr. Parmar disclaims beneficial ownership of such shares held directly by Opportunities LP, except to the extent of its or his pecuniary interest therein. Represents the principal amount of the Note. The outstanding principal and accrued interest on the convertible promissory note automatically converted into shares of Common Stock upon the closing of the IPO at a conversion price of $13.50 per share. 5AM Ventures V, L.P., By: 5AM Partners V, LLC, its General Partner, By /s/ Scott M. Rocklage, Managing Member 2021-04-29 /s/ Scott M. Rocklage 2021-04-29 /s/ Kush Parmar 2021-04-29 /s/ Scott M. Rocklage 2021-04-29 /s/ Andrew J. Schwab 2021-04-29 5AM Opportunities I, L.P., By: 5AM Opportunities I (GP), LLC, its General Partner, By /s/ Andrew J. Schwab, Managing Member 2021-04-29 5AM Opportunities I (GP), LLC, By /s/ Andrew J. Schwab, Managing Member 2021-04-29