X0306 4 2019-02-20 0 0001658247 Crinetics Pharmaceuticals, Inc. CRNX 0001589315 5AM Ventures IV, L.P. 501 2ND STREET, SUITE 350 SAN FRANCISCO CA 94107 0 0 1 0 0001593361 5AM Co-Investors IV, L.P. 501 2ND STREET, SUITE 350 SAN FRANCISCO CA 94107 0 0 1 0 0001589314 5AM Partners IV, LLC 501 2ND STREET, SUITE 350 SAN FRANCISCO CA 94107 0 0 1 0 0001219014 ROCKLAGE SCOTT M 501 2ND STREET, SUITE 350 SAN FRANCISCO CA 94107 0 0 1 0 0001240357 DIEKMAN JOHN D 501 2ND STREET, SUITE 350 SAN FRANCISCO CA 94107 0 0 1 0 0001598549 Schwab Andrew J. 501 2ND STREET, SUITE 350 SAN FRANCISCO CA 94107 0 0 1 0 Common Stock 2019-02-20 4 J 0 451200 0 D 2656442 I See foototes Common Stock 2019-02-20 4 J 0 18800 0 D 110683 I See foototes Common Stock 2019-02-20 4 J 0 4700 0 A 4700 I See footnote Common Stock 2019-02-20 4 J 0 4700 0 D 0 I See footnote Common Stock 2019-02-20 4 J 0 940 0 A 940 I See footnote Common Stock 2019-02-20 4 J 0 940 0 A 940 I See footnote Common Stock 2019-02-20 4 J 0 353 0 A 353 I See footnote Common Stock 2019-02-20 4 J 0 587 0 A 940 I See footnote Common Stock 2019-02-20 4 J 0 783 0 A 1723 I See footnote Common Stock 2019-02-20 4 J 0 783 0 A 1723 I See footnote Common Stock 2019-02-20 4 J 0 783 0 A 1723 I See footnote Represents a pro-rata in-kind distribution of Common Stock of the Issuer by 5AM Ventures IV, L.P. ("Ventures IV") without consideration to its partners. These securities are held of record by Ventures IV. Represents a pro-rata in-kind distribution of Common Stock of the Issuer by 5AM Co-Investors IV, L.P. ("Co-Investors IV") without consideration to its partners. These securities are held of record by Co-Investors IV. Represents a change in the form of ownership of 5AM Partners IV, LLC ("Partners IV") by virtue of the receipt of shares in the pro-rata in-kind distribution of Common Stock of the Issuer for no consideration by Ventures IV and Co-Investors IV. These securities are held of record by Partners IV. Represents a pro-rata in-kind distribution of Common Stock of the Issuer by Partners IV without consideration to its members. Partners IV is the sole general partner of Ventures IV and Co-Investors IV. Dr. John Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage, are the managing members of Partners IV, and have shared voting and investment power over the shares beneficially owned by Ventures IV and Co-Investors IV. Each of Partners IV, Dr. Diekman, Mr. Schwab, and Dr. Rocklage disclaims beneficial ownership of such shares except to the extent of its or their pecuniary interest therein. Represents the receipt of shares of Common Stock of the Issuer by virtue of the pro-rata in-kind distribution by Partners IV to the Schwab Family Trust, Andrew J. Schwab and Catarina N. Schwab, as Trustees of the Schwab Family Trust, dated October 26, 2007 ("Schwab Family Trust"). These securities are held of record by Schwab Family Trust. Mr. Schwab is a trustee and beneficiary of the Schwab Family Trust and disclaims beneficial ownership of these securities, except to the extent of his proportionate pecuniary interest therein. Represents the receipt of shares of Common Stock of the Issuer by virtue of the pro-rata in-kind distribution by Partners IV to John D. Diekman and Susan P. Diekman Trustees Diekman Revocable Trust Dtd 6/30/95 ("Diekman Trust"). These securities are held of record by Diekman Trust. Dr. Diekman is a trustee and beneficiary of the Diekman Trust and disclaims beneficial ownership of these securities, except to the extent of his proportionate pecuniary interest therein. Represents the receipt of shares of Common Stock of the Issuer by virtue of the pro-rata in-kind distribution by Partners IV to Scott M. Rocklage Revocable Trust dated March 2, 1999 as amended February 8, 2008; Trustees: Scott M. Rocklage and Patty B. Rocklage ("Rocklage Trust"). These securities are held of record by Rocklage Trust. Dr. Rocklage is a trustee and beneficiary of the Rocklage Trust and disclaims beneficial ownership of these securities, except to the extent of his proportionate pecuniary interest therein. Represents the receipt of shares of Common Stock of the Issuer by virtue of the pro-rata in-kind distribution by Partners IV to MADRock II LLC ("MADRock II"). These securities are held of record by MADRock II. Dr. Rocklage is a manager of MADRock II and disclaims beneficial ownership of these securities, except to the extent of his proportionate pecuniary interest therein. Represents the receipt of shares of Common Stock of the Issuer by virtue of the pro-rata in-kind distribution by Co-Investors IV to the Schwab Family Trust. Represents the receipt of shares of Common Stock of the Issuer by virtue of the pro-rata in-kind distribution by Co-Investors IV to the Diekman Trust. Represents the receipt of shares of Common Stock of the Issuer by virtue of the pro-rata in-kind distribution by Co-Investors IV to the Scott M. Rocklage Trust u/d/t/ dated October 22, 2015; Trustees: Scott M. Rocklage and Patty B. Rocklage ("Rocklage Trust II"). These securities are held of record by the Rocklage Trust II. Dr. Rocklage is a trustee and beneficiary of the Rocklage Trust II and disclaims beneficial ownership of these securities, except to the extent of his proportionate pecuniary interest therein. 5AM VENTURES IV, L.P. By: 5AM Partners IV, LLC, its General Partner /s/ Scott M. Rocklage Managing Member 2019-02-22 5AM CO-INVESTORS IV, L.P. By: 5AM Partners IV, LLC, its General Partner /s/ Scott M. Rocklage Managing Member 2019-02-22 5AM PARTNERS IV, LLC /s/ Scott M. Rocklage Managing Member 2019-02-22 /s/ Scott M. Rocklage 2019-02-22 /s/ John D. Diekman 2019-02-22 /s/ Andrew J. Schwab 2019-02-22