Condensed Consolidated Statements of Changes in Stockholders' Equity (Unaudited) - USD ($) $ in Thousands	Total	Common Stock [Member]	Treasury Stock [Member]	Additional Paid-in Capital [Member]	Accumulated Other Comprehensive Loss [Member]	Accumulated Deficit [Member]
Balances at Dec. 31, 2020	$ 2,072,334	$ 6	$ (400)	$ 3,109,807	$ 415	$ (1,037,494)
Balances, Shares at Dec. 31, 2020		58,308,411	3,033
Issuance of common stock from exercises of stock options, Amount	4,687			4,687
Issuance of common stock from exercises of stock options, Shares		80,338
Issuance of common stock under the employee stock purchase plan	936			936
Issuance of common stock under the employee stock purchase plan, Shares		18,072
Stock-based compensation expense	21,734			21,734
Change in unrealized loss on available-for-sale securities	(651)				(651)
Net loss	(95,764)					(95,764)
Balances at Mar. 31, 2021	2,003,276	$ 6	$ (400)	3,137,164	(236)	(1,133,258)
Balance, Shares at Mar. 31, 2021		58,406,821	3,033
Balances at Dec. 31, 2020	2,072,334	$ 6	$ (400)	3,109,807	415	(1,037,494)
Balances, Shares at Dec. 31, 2020		58,308,411	3,033
Net loss	(203,009)
Balances at Jun. 30, 2021	1,929,512	$ 6	$ (400)	3,170,694	(285)	(1,240,503)
Balance, Shares at Jun. 30, 2021		58,770,364	3,033
Balances at Mar. 31, 2021	2,003,276	$ 6	$ (400)	3,137,164	(236)	(1,133,258)
Balances, Shares at Mar. 31, 2021		58,406,821	3,033
Issuance of common stock from exercises of stock options, Amount	6,861			6,861
Issuance of common stock from exercises of stock options, Shares		159,070
Stock-based compensation expense	27,465			27,465
Change in unrealized loss on available-for-sale securities	(49)				(49)
Vesting of restricted stock units, net of employee tax obligations	(796)			(796)
Vesting of restricted stock units, net of employee tax obligations, Shares		204,473
Net loss	(107,245)					(107,245)
Balances at Jun. 30, 2021	1,929,512	$ 6	$ (400)	3,170,694	(285)	(1,240,503)
Balance, Shares at Jun. 30, 2021		58,770,364	3,033
Balances at Dec. 31, 2021	1,729,031	$ 6	$ (400)	3,227,471	(2,660)	(1,495,386)
Balances, Shares at Dec. 31, 2021		58,937,050	3,033
Issuance of common stock from exercises of stock options, Amount	646			646
Issuance of common stock from exercises of stock options, Shares		105,474
Issuance of common stock under the employee stock purchase plan	1,153			1,153
Issuance of common stock under the employee stock purchase plan, Shares		23,625
Stock-based compensation expense	18,268			18,268
Change in unrealized loss on available-for-sale securities	(8,541)				(8,541)
Net loss	(122,055)					(122,055)
Balances at Mar. 31, 2022	1,618,502	$ 6	$ (400)	3,247,538	(11,201)	(1,617,441)
Balance, Shares at Mar. 31, 2022		59,066,149	3,033
Balances at Dec. 31, 2021	1,729,031	$ 6	$ (400)	3,227,471	(2,660)	(1,495,386)
Balances, Shares at Dec. 31, 2021		58,937,050	3,033
Net loss	(248,315)
Balances at Jun. 30, 2022	1,504,236	$ 6	$ (400)	3,262,203	(13,872)	(1,743,701)
Balance, Shares at Jun. 30, 2022		59,388,729	3,033
Balances at Mar. 31, 2022	1,618,502	$ 6	$ (400)	3,247,538	(11,201)	(1,617,441)
Balances, Shares at Mar. 31, 2022		59,066,149	3,033
Issuance of common stock from exercises of stock options, Amount	37			37
Issuance of common stock from exercises of stock options, Shares		31,801
Stock-based compensation expense	14,652			14,652
Change in unrealized loss on available-for-sale securities	(2,671)				(2,671)
Vesting of restricted stock units, net of employee tax obligations	(24)			(24)
Vesting of restricted stock units, net of employee tax obligations, Shares		290,779
Net loss	(126,260)					(126,260)
Balances at Jun. 30, 2022	$ 1,504,236	$ 6	$ (400)	$ 3,262,203	$ (13,872)	$ (1,743,701)
Balance, Shares at Jun. 30, 2022		59,388,729	3,033