Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Income Statement [Abstract]
Total revenue	$ 1,501	$ 1,643	$ 3,082	$ 3,226
Operating costs and expenses:
Cost of goods sold	200	148	486	335
Research and development	77,297	66,170	155,315	124,226
Selling, general and administrative	52,411	43,346	98,888	83,193
Total operating costs and expenses	129,908	109,664	254,689	207,754
Loss from operations	(128,407)	(108,021)	(251,607)	(204,528)
Interest income, net	2,102	732	3,270	1,440
Other income, net	45	44	22	79
Net loss	$ (126,260)	$ (107,245)	$ (248,315)	$ (203,009)
Net loss per share—basic	$ (2.13)	$ (1.83)	$ (4.20)	$ (3.47)
Net loss per share—diluted	$ (2.13)	$ (1.83)	$ (4.20)	$ (3.47)
Weighted average number of common shares outstanding— basic	59,266,322	58,582,569	59,148,246	58,478,970
Weighted average number of common shares outstanding— diluted	59,266,322	58,582,569	59,148,246	58,478,970
Comprehensive loss:
Net loss	$ (126,260)	$ (107,245)	$ (248,315)	$ (203,009)
Other comprehensive items:
Unrealized loss on marketable securities	(2,671)	(49)	(11,212)	(700)
Total other comprehensive loss	(2,671)	(49)	(11,212)	(700)
Total comprehensive loss	$ (128,931)	$ (107,294)	$ (259,527)	$ (203,709)