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Stock-Based Compensation - Additional Information (Detail)
3 Months Ended 6 Months Ended 12 Months Ended
Jun. 16, 2022
shares
Jan. 01, 2022
shares
Jun. 30, 2022
USD ($)
shares
Mar. 31, 2022
shares
Jun. 30, 2021
USD ($)
shares
Mar. 31, 2021
USD ($)
shares
Jun. 30, 2020
shares
Jun. 30, 2022
USD ($)
Milestone
$ / shares
shares
Jun. 30, 2021
USD ($)
Milestone
$ / shares
shares
Dec. 31, 2021
shares
Dec. 31, 2020
Sep. 20, 2018
shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                        
Share based compensation granted under plan vested period               4 years        
Share based compensation, vest period               1 year        
Share based compensation, term of plan               10 years        
Total number of shares outstanding     9,089,284         9,089,284        
Common stock available for issuance under stock option plan     7,328,205         7,328,205        
Issuance of common stock under the employee stock purchase plan, Shares 300,000                      
Stock-based compensation expense | $     $ 14,636,000   $ 27,663,000     $ 33,189,000 $ 49,639,000      
Weighted average grant date fair value per share | $ / shares               $ 26.32 $ 54.51      
Time Based Restricted Stock Units [Member]                        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                        
Share based compensation granted under plan vested period             2 years          
Restricted stock units granted             550,890 0 0      
Restricted stock units vested     291,505 0 113,941 0            
Fair value of restricted stock units vested | $     $ 9,500,000   $ 8,800,000              
Outstanding and unvested restricted stock units     243,159         243,159        
Total unrecognized stock-based compensation expense | $     $ 7,800,000         $ 7,800,000        
Performance Restricted Stock Units [Member]                        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                        
Outstanding and unvested restricted stock units     1,164,660         1,164,660        
Total unrecognized stock-based compensation expense | $     $ 69,900,000         $ 69,900,000        
Stock Options [Member]                        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                        
Options granted               894,067        
Total number of shares outstanding     7,681,465         7,681,465   7,283,439    
Stock-based compensation expense | $     $ 13,202,000   $ 21,545,000     $ 28,667,000 $ 41,224,000      
Total unrecognized stock-based compensation expense | $     77,700,000         $ 77,700,000        
Weighted average period of unrecognized compensation costs               2 years 9 months        
Intrinsic value of options exercised | $               $ 4,200,000 7,500,000      
Performance-Based Stock Options [Member]                        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                        
Stock-based compensation expense | $               $ 0 $ 0      
Milestones achieved | Milestone               0 0      
Performance Shares [Member]                        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                        
Options granted         0     0        
Total unrecognized stock-based compensation expense | $     $ 11,400,000         $ 11,400,000        
Number of shares outstanding and unvested stock options     681,649         681,649        
Performance Shares [Member] | Chief Executive Officer [Member]                        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                        
Options granted           650,000            
Restricted Stock Units Vest One Year Anniversary [Member]                        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                        
Restricted stock units vesting percentage               25.00%        
Restricted Stock Units Vest One Year Anniversary [Member] | Time Based Restricted Stock Units [Member]                        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                        
Restricted stock units vesting percentage             25.00%          
Restricted stock units vesting period month and year             2021-04          
Share-Based Payment Arrangement, Tranche Two | Time Based Restricted Stock Units [Member]                        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                        
Restricted stock units vesting percentage             75.00%          
Restricted stock units vesting period month and year             2022-04          
2011 Plan [Member]                        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                        
Options granted               0        
2014 Plan [Member]                        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                        
Common stock shares annual increase added to plan   2,357,482                    
2014 Plan [Member] | Performance Restricted Stock Units [Member]                        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                        
Restricted stock units granted     96,365   31,400     511,930 373,121      
Fair value of restricted stock units vested | $         $ 6,100,000 $ 0   $ 0        
Milestone performance restricted stock percentage                     39  
Stock-based compensation expense | $               $ 0 $ 0      
2014 Plan [Member] | Maximum [Member]                        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                        
Percentage of increase on outstanding shares of Common stock                   4.00%    
2016 Plan [Member]                        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                        
Total number of shares reserved for issuance                       1,200,000