Stock-Based Compensation (Tables)

6 Months Ended

Jun. 30, 2022

Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]

Summary of Activity Relating to Restricted Stock Units

The table below summarizes activity relating to time-based restricted stock units and performance restricted stock units:

	Shares
Outstanding as of December 31, 2021		1,256,098
Granted		511,930
Vested		(291,505	)
Forfeited		(68,704	)
Outstanding as of June 30, 2022		1,407,819

Summary of Activity Relating to Time Based and Performance Based Stock Options

The table below summarizes activity related to time-based and performance-based stock options:

	Shares			Weighted Average Exercise Price		Weighted Average Remaining Life (in years)		Aggregate Intrinsic Value (in thousands)
Outstanding as of December 31, 2021		7,283,439		$	84.17		6.74	$	16,590
Granted		894,067		$	40.18
Exercised		(137,275	)	$	4.98
Forfeited		(358,766	)	$	93.52
Outstanding as of June 30, 2022		7,681,465		$	80.03		6.74	$	3,279
Exercisable as of June 30, 2022		4,841,021		$	85.85		5.55	$	3,203

Summary of Stock-Based Compensation Expense Recognized

Stock-based compensation expense recognized during the three and six months ended June 30, 2022 and 2021 was as follows:

	Three Months Ended June 30,				Six Months Ended June 30,
	2022		2021		2022		2021
	(in thousands)
Research and development	$	6,458	$	13,453	$	15,073	$	22,734
Selling, general and administrative		8,178		14,210		18,116		26,905
	$	14,636	$	27,663	$	33,189	$	49,639

Summary of Stock-Based Compensation Expense by Award Type

Stock-based compensation expense recognized during the three and six months ended June 30, 2022 and 2021 by award type was as follows:

	Three Months Ended June 30,					Six Months Ended June 30,
	2022			2021		2022		2021
	(in thousands)
Stock options	$	13,202		$	21,545	$	28,667	$	41,224
Restricted stock units		1,450			5,920		4,253		7,975
Employee stock purchase plan		(16	)		198		269		440
	$	14,636		$	27,663	$	33,189	$	49,639