Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Income Statement [Abstract]
Total revenue	$ 1,582	$ 1,583
Operating costs and expenses:
Cost of goods sold	286	187
Research and development	78,018	58,056
Selling, general and administrative	46,477	39,847
Total operating costs and expenses	124,781	98,090
Loss from operations	(123,199)	(96,507)
Interest income, net	1,168	708
Other income (expense), net	(24)	35
Net loss	$ (122,055)	$ (95,764)
Net loss per share—basic and diluted	$ (2.07)	$ (1.64)
Weighted average number of common shares outstanding—basic and diluted	59,028,858	58,374,219
Comprehensive loss:
Net loss	$ (122,055)	$ (95,764)
Other comprehensive items:
Unrealized loss on marketable securities	(8,541)	(651)
Total other comprehensive loss	(8,541)	(651)
Total comprehensive loss	$ (130,596)	$ (96,415)