Nature of the Business - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended	144 Months Ended
	Mar. 31, 2022	Dec. 31, 2020	Mar. 31, 2022	Dec. 31, 2021
Nature Of Business [Line Items]
Accumulated deficit	$ 1,617,441		$ 1,617,441	$ 1,495,386
Net income from up-front		$ 606,100
Up-front payments receive	$ 1,000,000
Redeemable Convertible Preferred Stock [Member] | Convertible Notes [Member] | Initial Public Offering [Member]
Nature Of Business [Line Items]
Net proceeds from sale of equity and notes			$ 2,800,000