Stock-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2022

Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]

Summary of Activity Relating to Restricted Stock Units

The table below summarizes activity relating to time-based restricted stock units and performance restricted stock units:

	Shares
Outstanding as of December 31, 2021		1,256,098
Granted		415,565
Vested		—
Forfeited		(47,659	)
Outstanding as of March 31, 2022		1,624,004

Summary of Activity Relating to Time Based and Performance Based Stock Options

The table below summarizes activity related to time-based and performance-based stock options:

	Shares			Weighted Average Exercise Price		Weighted Average Remaining Life (in years)		Aggregate Intrinsic Value (in thousands)
Outstanding as of December 31, 2021		7,283,439		$	84.17		6.74	$	16,590
Granted		662,208		$	42.71
Exercised		(105,474	)	$	6.13
Forfeited		(224,971	)	$	78.31
Outstanding as of March 31, 2022		7,615,202		$	81.82		6.86	$	4,532
Exercisable as of March 31, 2022		4,476,344		$	88.64		5.51	$	4,529

Summary of Stock-Based Compensation Expense Recognized

Stock-based compensation expense recognized during the three months ended March 31, 2022 and 2021 was as follows:

	Three Months Ended March 31,
	2022		2021
	(in thousands)
Research and development	$	8,615	$	9,281
Selling, general and administrative		9,938		12,695
	$	18,553	$	21,976

Summary of Stock-Based Compensation Expense by Award Type

Stock-based compensation expense recognized during the three months ended March 31, 2022 and 2021 by award type was as follows:

	Three Months Ended March 31,
	2022		2021
	(in thousands)
Stock options	$	15,465	$	19,679
Restricted stock units		2,803		2,055
Employee stock purchase plan		285		242
	$	18,553	$	21,976