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Stock-Based Compensation - Summary of Activity Relating to Time Based and Performance Based Stock Options (Detail) - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Ending balance, Outstanding Shares 8,539,537  
Stock Options [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Beginning balance, Outstanding Shares 7,157,830  
Granted, Shares 2,095,363  
Exercised, Shares (306,078)  
Forfeited, Shares (1,663,676)  
Ending balance, Outstanding Shares 7,283,439 7,157,830
Vested and expected to vest, Shares 6,220,652  
Exercisable, Shares 4,434,049  
Beginning balance, Outstanding Weighted Average Exercise Price $ 91.41  
Granted, Weighted Average Exercise Price 79.76  
Exercised, Weighted Average Exercise Price 40.35  
Forfeited, Weighted Average Exercise Price 117.80  
Ending balance, Outstanding Weighted Average Exercise Price 84.17 $ 91.41
Vested and expected to vest, Weighted Average Exercise Price 84.00  
Exercisable, Weighted Average Exercise Price $ 85.68  
Outstanding, Weighted Average Remaining Life 6 years 8 months 26 days 6 years 10 months 28 days
Vested and expected to vest, Weighted Average Remaining Life 6 years 4 months 13 days  
Exercisable, Weighted Average Remaining Life 5 years 5 months 19 days  
Outstanding, Aggregate Intrinsic Value $ 16,590 $ 167,242
Vested and expected to vest, Aggregate Intrinsic Value 16,493  
Exercisable, Aggregate Intrinsic Value $ 15,713