Consolidated Statements of Changes in Stockholders' Equity - USD ($) $ in Thousands	Total	Common Stock [Member]	Treasury Stock [Member]	Additional Paid-in Capital [Member]	Accumulated Other Comprehensive Loss [Member]	Accumulated Deficit [Member]
Balances at Dec. 31, 2018	$ 862,971	$ 5	$ (211)	$ 1,827,021	$ (515)	$ (963,329)
Balances, Shares at Dec. 31, 2018		46,888,263	3,033
Issuance of common stock from exercise of stock options, Amount	44,276			44,276
Issuance of common stock from exercise of stock options, Shares		1,031,989
Issuance of common stock under the employee stock purchase plan	5,744			5,744
Issuance of common stock under the employee stock purchase plan, Shares		55,404
Stock-based compensation expense	151,508			151,508
Purchase of treasury stock, Amount	(189)		$ (189)
Public offering of common stock, net of offering costs, Amount	560,948			560,948
Public offering of common stock, net of offering costs, Shares		3,833,334
Vesting of restricted stock units, net of employee tax obligations	(2,175)			(2,175)
Vesting of restricted stock units, net of employee tax obligations, Shares		68,204
Unrealized gain (loss) on available-for-sale securities	1,810				1,810
Net income (loss)	(680,238)					(680,238)
Balances at Dec. 31, 2019	944,655	$ 5	$ (400)	2,587,322	1,295	(1,643,567)
Balances, Shares at Dec. 31, 2019		51,877,194	3,033
Issuance of common stock from exercise of stock options, Amount	5,082			5,082
Issuance of common stock from exercise of stock options, Shares		117,025
Issuance of common stock under the employee stock purchase plan	4,936			4,936
Issuance of common stock under the employee stock purchase plan, Shares		72,719
Issuance of common stock under the Stock Purchase Agreement - related party	417,500	$ 1		417,499
Issuance of common stock under the Stock Purchase Agreement - related party, Shares		6,241,473
Stock-based compensation expense	$ 94,968			94,968
Public offering of common stock, net of offering costs, Shares	6,241,473
Unrealized gain (loss) on available-for-sale securities	$ (880)				(880)
Net income (loss)	606,073					606,073
Balances at Dec. 31, 2020	2,072,334	$ 6	$ (400)	3,109,807	415	(1,037,494)
Balances, Shares at Dec. 31, 2020		58,308,411	3,033
Issuance of common stock from exercise of stock options, Amount	12,397			12,397
Issuance of common stock from exercise of stock options, Shares		307,378
Issuance of common stock under the employee stock purchase plan	2,761			2,761
Issuance of common stock under the employee stock purchase plan, Shares		46,759
Stock-based compensation expense	$ 103,891			103,891
Purchase of treasury stock, Shares	(3,033)
Vesting of restricted stock units, net of employee tax obligations	$ (1,385)			(1,385)
Vesting of restricted stock units, net of employee tax obligations, Shares		274,502
Unrealized gain (loss) on available-for-sale securities	(3,075)				(3,075)
Net income (loss)	(457,892)					(457,892)
Balances at Dec. 31, 2021	$ 1,729,031	$ 6	$ (400)	$ 3,227,471	$ (2,660)	$ (1,495,386)
Balances, Shares at Dec. 31, 2021		58,937,050	3,033