Consolidated Statements of Operations and Comprehensive Income (Loss) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Total revenue	$ 6,308	$ 1,114,200	$ 6,868
Operating costs and expenses:
Cost of goods sold	553	565	400
Research and development	283,166	292,714	368,815
Selling, general and administrative	183,498	196,952	345,777
Restructuring		27,743
Total operating costs and expenses	467,217	517,974	714,992
Income (loss) from operations	(460,909)	596,226	(708,124)
Interest income, net	2,883	9,597	27,804
Other income, net	134	250	82
Net income (loss)	$ (457,892)	$ 606,073	$ (680,238)
Net income (loss) per share—basic	$ (7.80)	$ 11.66	$ (13.38)
Net income (loss) per share—diluted	$ (7.80)	$ 11.43	$ (13.38)
Weighted average number of common shares outstanding—basic	58,670,230	51,983,188	50,833,837
Weighted average number of common shares outstanding—diluted	58,670,230	53,003,115	50,833,837
Comprehensive income (loss):
Net income (loss)	$ (457,892)	$ 606,073	$ (680,238)
Other comprehensive items:
Unrealized gain (loss) on marketable securities	(3,075)	(880)	1,810
Total other comprehensive gain (loss)	(3,075)	(880)	1,810
Total comprehensive income (loss)	(460,967)	605,193	(678,428)
Product Revenue [Member]
Total revenue	$ 6,308	6,700	3,957
Collaboration Revenue [Member]
Total revenue			$ 2,911
Collaboration Revenue - Related Party [Member]
Total revenue		$ 1,107,500