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Stock-Based Compensation - Additional Information (Detail) - USD ($)
3 Months Ended 9 Months Ended 12 Months Ended
Jan. 01, 2021
Jan. 01, 2019
Sep. 30, 2021
Jun. 30, 2021
Mar. 31, 2021
Sep. 30, 2020
Jun. 30, 2020
Sep. 30, 2021
Sep. 30, 2020
Dec. 31, 2020
Sep. 20, 2018
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Share based compensation granted under plan vested period             2 years 4 years      
Share based compensation, vest period               1 year      
Share based compensation, term of plan               10 years      
Total number of shares outstanding     8,644,442         8,644,442      
Common stock available for issuance under stock option plan     5,687,262         5,687,262      
Restricted stock units granted             550,890 0      
Restricted stock units vested       113,941              
Fair value of restricted stock units vested       $ 8,800,000              
Stock-based compensation expense     $ 34,342,000     $ 20,108,000   $ 83,981,000 $ 75,250,000    
Outstanding and unvested restricted stock units     1,006,718         1,006,718      
Weighted average grant date fair value per share               $ 53.42 $ 37.04    
Restricted Stock Units [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Restricted stock units granted               420,161      
Stock-based compensation expense     $ 14,563,000     $ 1,066,000   $ 22,538,000 $ 1,815,000    
Outstanding and unvested restricted stock units     1,006,718         1,006,718   957,695  
Performance Restricted Stock Units [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Fair value of restricted stock units vested       6,100,000         $ 0    
Milestone performance restricted stock percentage                   39  
Total unrecognized stock-based compensation expense     $ 64,700,000         $ 64,700,000      
Performance Restricted Stock Units [Member] | Commercial Milestones [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Restricted stock units granted     47,040     11,800   420,161 444,616    
Stock-based compensation expense     $ 12,600,000 $ 3,800,000              
Stock Options [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Options granted               1,967,133      
Total number of shares outstanding     7,637,724         7,637,724   7,157,830  
Stock-based compensation expense     $ 19,516,000     $ 18,797,000   $ 60,740,000 $ 72,434,000    
Total unrecognized stock-based compensation expense     115,800,000         $ 115,800,000      
Weighted average period of unrecognized compensation costs               2 years 3 months      
Intrinsic value of options exercised               $ 8,000,000.0 900,000    
Performance Shares [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Options granted   0                  
Total unrecognized stock-based compensation expense     $ 26,200,000         $ 26,200,000      
Number of shares outstanding and unvested stock options     908,726         908,726      
Performance Shares [Member] | Chief Executive Officer [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Options granted         650,000            
Performance-Based Stock Options [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Stock-based compensation expense               $ 0 $ 0    
Restricted Stock Units Vest One Year Anniversary [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Restricted stock units cliff vesting percentage               25.00%      
Restricted Stock Units Vest One Year Anniversary [Member] | Restricted Stock Units [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Restricted stock units cliff vesting percentage             25.00%        
Restricted stock units vesting period month and year             2021-04        
Restricted Stock Units Vest Two Year Anniversary [Member] | Restricted Stock Units [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Restricted stock units cliff vesting percentage             75.00%        
Restricted stock units vesting period month and year             2022-04        
2011 Plan [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Options granted               0      
2014 Plan [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Common stock shares annual increase added to plan 2,332,336                    
2014 Plan [Member] | Maximum [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Percentage of increase on outstanding shares of Common stock                   4.00%  
2016 Plan [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Total number of shares reserved for issuance                     1,200,000