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Collaboration Agreements - Summary of Operating Expenses Category Related to Collaboration Agreement (Detail) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Net reimbursement from Biogen reflected in the condensed consolidated statement of operations and comprehensive loss:        
Research and development expenses $ (66,170) $ (73,320) $ (124,226) $ (136,930)
Selling, general and administrative expenses (43,346) (38,224) (83,193) (108,355)
Total operating costs and expenses 109,664 $ 140,056 207,754 $ 273,967
Biogen Collaboration Agreement [Member]        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Expenses related to the Biogen Collaboration Agreement incurred by Sage 48,866   98,703  
Net reimbursement from Biogen reflected in the condensed consolidated statement of operations and comprehensive loss:        
Research and development expenses (20,141)   (42,209)  
Selling, general and administrative expenses (3,531)   (6,229)  
Total operating costs and expenses $ 25,194   $ 50,265