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Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($)
3 Months Ended 6 Months Ended
Mar. 31, 2019
Jun. 30, 2019
Jan. 01, 2019
Dec. 31, 2018
Summary Of Significant Accounting Policies [Line Items]        
Intangible assets       $ 0
Amortization of intangible assets $ 0      
Operating lease liabilities   $ 40,702,000 $ 44,200,000  
Operating lease right-of-use asset   $ 37,224,000 $ 41,100,000  
CyDex License Agreement [Member]        
Summary Of Significant Accounting Policies [Line Items]        
Milestone payments 3,000,000.0      
The Regents of University of California [Member]        
Summary Of Significant Accounting Policies [Line Items]        
Milestone payments $ 500,000      
Product Revenue [Member]        
Summary Of Significant Accounting Policies [Line Items]        
Incremental costs incurred expected amortization period of asset   true