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Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($)
3 Months Ended
Mar. 31, 2019
Jan. 01, 2019
Dec. 31, 2018
Summary Of Significant Accounting Policies [Line Items]      
Intangible assets     $ 0
Amortization of intangible assets $ 0    
Operating lease liabilities 41,677,000 $ 44,200,000  
Operating lease right-of-use asset 38,124,000 $ 41,100,000  
CyDex License Agreement [Member]      
Summary Of Significant Accounting Policies [Line Items]      
Milestone payments 3,000,000    
The Regents of University of California [Member]      
Summary Of Significant Accounting Policies [Line Items]      
Milestone payments $ 500,000