Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Cash flows from operating activities
Net loss	$ (372,882)	$ (270,120)	$ (158,987)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation expense	101,963	35,534	23,020
Premium on marketable securities	(215)	(105)	(756)
Amortization of premium (discount) on marketable securities	(9,892)	(293)	286
Depreciation	1,143	531	281
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	(15,462)	(1,127)	(3,362)
Accounts payable	24,544	(3,693)	7,796
Accrued expenses and other liabilities	10,130	19,996	13,044
Net cash used in operating activities	(260,671)	(219,277)	(118,678)
Cash flows from investing activities
Proceeds from sales and maturities of marketable securities	974,757	261,225	30,499
Purchases of marketable securities	(1,484,358)	(244,403)	(259,093)
Purchases of property and equipment	(2,860)	(1,360)	(1,421)
Net cash provided by (used in) investing activities	(512,461)	15,462	(230,015)
Cash flows from financing activities
Proceeds from stock option exercises and employee stock purchase plan issuances	29,108	15,972	1,406
Payment of employee tax obligations related to vesting of restricted stock units	(904)
Payments of offering costs	(340)	(179)	(599)
Proceeds from public offerings of common stock, net of commissions and underwriting discounts	631,494	326,025	330,175
Net cash provided by financing activities	659,358	341,818	330,982
Net increase (decrease) in cash, cash equivalents and restricted cash	(113,774)	138,003	(17,711)
Cash, cash equivalents and restricted cash at beginning of period	307,084	169,081	186,792
Cash, cash equivalents and restricted cash at end of period	193,310	307,084	169,081
Supplemental disclosure of non-cash operating, investing and financing activities
Landlord tenant incentive included in other current assets	229
Purchases of property and equipment financed with landlord tenant incentive		1,665
Purchases of property and equipment included in accounts payable	$ 51	138	$ 8
Public offering costs included in accounts payable		$ 95

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