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Net Loss Per Share - Summary of Basic and Diluted Net Loss Per Share (Detail) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Numerator:                      
Net loss $ (158,388) $ (122,918) $ (16,978) $ (74,598) $ (69,421) $ (73,719) $ (70,202) $ (56,778) $ (372,882) $ (270,120) $ (158,987)
Denominator:                      
Weighted average common stock outstanding - basic                 46,121,194 38,113,678 33,492,795
Dilutive effect of shares of common stock equivalents resulting from common stock options and restricted stock units                 0 0 0
Weighted average common stock outstanding - diluted                 46,121,194 38,113,678 33,492,795
Net loss per share—basic and diluted $ (3.38) $ (2.63) $ (0.36) $ (1.68) $ (1.75) $ (1.97) $ (1.88) $ (1.52) $ (8.08) $ (7.09) $ (4.75)