Net Loss Per Share (Tables)

6 Months Ended

Jun. 30, 2018

Summary of Basic and Diluted Net Loss Per Share

Basic and diluted net loss per share was calculated as follows for the three and six months ended June 30, 2018 and 2017:

	Three months ended June 30,						Six months ended June 30,
	2018			2017			2018			2017
Basic net loss per share:
Numerator:
Net loss (in thousands)	$	(16,978	)	$	(70,202	)	$	(91,576	)	$	(126,979	)
Denominator:
Weighted average common stock outstanding —basic		46,541,716			37,361,129			45,439,666			37,315,393
Dilutive effect of shares of common stock equivalents resulting from common stock options and restricted stock units		—			—			—			—
Weighted average common stock outstanding —diluted		46,541,716			37,361,129			45,439,666			37,315,393
Net loss per share—basic and diluted	$	(0.36	)	$	(1.88	)	$	(2.02	)	$	(3.40	)

Summary of Anti-Dilutive Common Stock Equivalents Outstanding

The following common stock equivalents outstanding as of June 30, 2018 and 2017 were excluded from the computation of diluted net loss per share for the periods presented because including them would have been anti-dilutive:

	Three months ended June 30,				Six months ended June 30,
	2018		2017		2018		2017
Stock options		6,207,172		5,313,821		6,207,172		5,313,821
Restricted stock units		13,950		30,400		13,950		30,400
Employee stock purchase plan		8,004		8,697		8,004		8,697
		6,229,126		5,352,918		6,229,126		5,352,918