Selected Quarterly Financial Data (Unaudited)

12 Months Ended

Dec. 31, 2017

Quarterly Financial Information Disclosure [Abstract]

Selected Quarterly Financial Data (Unaudited)

12. Selected Quarterly Financial Data (Unaudited)

The following table contains quarterly financial information for 2017 and 2016. The Company believes that the following information reflects all normal recurring adjustments necessary for a fair statement of the information for the periods presented. The operating results for any quarter are not necessarily indicative of results for any future period.

	2017
	First Quarter			Second Quarter			Third Quarter			Fourth Quarter			Total
	(in thousands, except per share amounts)
Total operating expenses	$	57,480		$	70,854		$	74,373		$	70,448		$	273,155
Loss from operations		(57,480	)		(70,854	)		(74,373	)		(70,448	)		(273,155	)
Net loss		(56,778	)		(70,202	)		(73,719	)	$	(69,421	)		(270,120	)
Net loss per share—basic and diluted	$	(1.52	)	$	(1.88	)	$	(1.97	)	$	(1.75	)	$	(7.09	)

	2016
	First Quarter			Second Quarter			Third Quarter			Fourth Quarter			Total
	(in thousands, except per share amounts)
Total operating expenses	$	30,714		$	35,006		$	38,064		$	56,379		$	160,163
Loss from operations		(30,714	)		(35,006	)		(38,064	)		(56,379	)		(160,163	)
Net loss		(30,543	)		(34,747	)		(37,796	)		(55,901	)		(158,987	)
Net loss per share—basic and diluted	$	(0.97	)	$	(1.08	)	$	(1.15	)	$	(1.50	)	$	(4.75	)