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Stock-Based Compensation - Summary of Activity Relating to Stock Options (Detail) - Options to Purchase Common Stock [Member] - USD ($)
$ / shares in Units, $ in Thousands
9 Months Ended 12 Months Ended
Sep. 30, 2016
Dec. 31, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Beginning balance, Outstanding Shares-Stock options 3,002,809  
Granted, Stock options 1,213,068  
Exercised, Stock options (69,822)  
Forfeited, Stock options (84,775)  
Ending balance, Outstanding Shares-Stock options 4,061,280 3,002,809
Vested and expected to vest as of September 30, 2016 3,327,569  
Exercisable as of September 30, 2016 1,363,896  
Beginning balance, Outstanding Weighted Average Exercise Price-Stock options $ 26.67  
Granted, Weighted Average Exercise Price-Stock options 33.68  
Exercised, Weighted Average Exercise Price-Stock options 4.52  
Forfeited, Weighted Average Exercise Price-Stock options 46.47  
Ending balance, Outstanding Weighted Average Exercise Price-Stock options 28.74 $ 26.67
Vested and expected to vest, Weighted Average Exercise Price-Stock options 27.53  
Exercisable, Weighted Average Exercise Price-Stock options $ 21.87  
Outstanding, Weighted Average Remaining Life-Stock options 8 years 4 months 21 days 8 years 8 months 1 day
Vested and expected to vest as of September 30, 2016 8 years 3 months 29 days  
Exercisable as of September 30, 2016 7 years 8 months 23 days  
Outstanding, Aggregate Intrinsic Value-Stock options $ 76,947 $ 96,479
Vested and expected to vest as of September 30, 2016 67,698  
Exercisable as of September 30, 2016 $ 35,845