X0306 4 2023-02-03 false 0001597553 Sage Therapeutics, Inc. SAGE 0001320559 Cook Anne Marie C/O SAGE THERAPEUTICS, INC. 215 FIRST STREET CAMBRIDGE MA 02142 false true false false SVP, GC & Secretary Common Stock 2023-02-03 4 A false 2850.00 0.00 A 11478.00 D Common Stock 2023-02-03 4 F false 980.00 44.16 D 10498.00 D On February 10, 2021, the reporting person was granted Performance Stock Units (PSUs) to acquire a total of 9,500 shares of common stock. The PSUs vest upon the achievement of certain milestones, one of which was met on February 3, 2023, resulting in the vesting of the PSUs as to 2,850 shares. Reflects beneficial ownership balance which includes 221 shares purchased on June 30, 2022 and 432 shares purchased on December 31, 2022, each under the Sage Therapeutics, Inc. 2014 Employee Stock Purchase Plan. /s/ Anne Marie Cook 2023-02-07