X0306 4 2022-05-05 false 0001597553 Sage Therapeutics, Inc. SAGE 0001586660 Golumbeski George C/O SAGE THERAPEUTICS, INC. 215 FIRST STREET CAMBRIDGE MA 02142 true false false false Common Stock 2022-05-05 4 P false 8000.00 31.4454 A 8000.00 D This transaction was executed in multiple trades at prices ranging from $31.33 USD to $31.50 USD. The price reported above reflects the weighted average sale price. The issuer hereby undertakes to provide, upon request, to the SEC staff or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. /s/ Jennifer Fitzpatrick, as Attorney-in-Fact for George Golumbeski 2022-05-09