X0306 5 2014-12-31 0 0 1 0001597553 Sage Therapeutics, Inc. SAGE 0001612859 Kanes Stephen C/O SAGE THERAPEUTICS, INC., 215 FIRST STREET CAMBRIDGE MA 02142 0 1 0 0 Chief Medical Officer Common Stock 2014-08-28 4 M 0 60186 0.45 A 63186 D Common Stock 2014-08-28 4 M 0 1162 1.36 A 64348 D Stock Option (right to buy) 0.45 2014-08-28 4 M 0 60186 0.00 D 2023-07-18 Common Stock 60186 162036 D Stock Option (right to buy) 1.36 2014-08-28 4 M 0 1162 0.00 D 2024-01-01 Common Stock 1162 6774 D The option, representing a right to purchase a total of 222,222 shares, became partially exercisable beginning on July 18, 2014. 25% of this option vested on July 18, 2014 and the remainder vests in equal monthly installments thereafter over 36 months. The option, representing a right to purchase a total of 7,936 shares, vests in equal monthly installments over 48 months beginning on January 1, 2014. /s/ Stephen Kanes 2015-01-26