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Stock-Based Compensation - Summary of Activity Relating to Stock Options (Detail) - Options to Purchase Common Stock [Member] - USD ($)
$ / shares in Units, $ in Thousands
6 Months Ended 12 Months Ended
Jun. 30, 2016
Dec. 31, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Beginning balance, Stock options 3,002,809  
Granted, Stock options 969,785  
Exercised, Stock options (57,142)  
Forfeited, Stock options (36,900)  
Ending balance, Outstanding Shares-Stock options 3,878,552 3,002,809
Vested and expected to vest, Stock options 3,168,000  
Exercisable, Stock options 1,135,287  
Beginning balance, Weighted Average Exercise Price-Stock options $ 26.67  
Granted, Weighted Average Exercise Price-Stock options 32.25  
Exercised, Weighted Average Exercise Price-Stock options 1.47  
Forfeited, Weighted Average Exercise Price-Stock options 56.07  
Ending balance, Outstanding Weighted Average Exercise Price-Stock options 28.16 $ 26.67
Vested and expected to vest, Weighted Average Exercise Price-Stock options 26.93  
Exercisable, Weighted Average Exercise Price-Stock options $ 20.40  
Outstanding, Weighted Average Remaining Life-Stock options 8 years 6 months 18 days 8 years 8 months 1 day
Vested and expected to vest, Weighted Average Remaining Life-Stock options 8 years 5 months 27 days  
Exercisable, Weighted Average Remaining Life-Stock options 7 years 10 months 28 days  
Outstanding, Aggregate Intrinsic Value-Stock options $ 34,015 $ 96,479
Vested and expected to vest, Aggregate Intrinsic Value-Stock options 31,690  
Exercisable, Aggregate Intrinsic Value-Stock options $ 17,403