Stock-Based Compensation - Additional Information (Detail)				12 Months Ended
	Jun. 10, 2024 shares	Feb. 21, 2024 $ / shares shares	Jun. 15, 2023 shares	Dec. 31, 2024 USD ($) Milestone $ / shares shares	Dec. 31, 2023 USD ($) Milestone $ / shares shares	Dec. 31, 2022 USD ($) Milestone $ / shares shares	Apr. 16, 2024 shares	Jan. 23, 2024 $ / shares	Jun. 16, 2022 shares	Sep. 20, 2018 shares	Jul. 02, 2014 shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share based compensation granted under plan vested period				4 years
Share based compensation, vest period				1 year
Share based compensation, term of plan				10 years
Stock-based compensation expense | $				$ 54,504,000	$ 73,367,000	$ 61,602,000
Stock-based compensation expense tied to total stockholder return | $				$ 54,504,000	$ 73,367,000	$ 61,602,000
Weighted average grant date fair value per share | $ / shares				$ 14.23	$ 29.53	$ 25.96
Share option, weighted-average forfeiture rates				15.10%	16.60%	19.20%
Restructuring [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense | $				$ 32,000	$ 838,000	$ 0
Time Based Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock units granted				938,470	1,734,717	0
Restricted stock units vested				272,844	51,851	366,014
Fair value of restricted stock units vested | $				$ 2,800,000	$ 1,800,000	$ 12,400,000
Outstanding and unvested restricted stock units				1,788,137
Total unrecognized stock-based compensation expense | $				$ 13,800,000
Weighted average period of unrecognized compensation costs				1 year 5 months 4 days
Performance Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock units granted				400,455	905,012	705,380
Fair value of restricted stock units vested | $						$ 0
Stock-based compensation expense | $				$ 4,000,000	$ 0	0
Stock-based compensation expense to be recognized | $				400,000
Stock-based compensation expense tied to total stockholder return | $				$ 800,000	$ 700,000
Outstanding and unvested restricted stock units				1,212,253
Total unrecognized stock-based compensation expense | $				$ 42,900,000
Stock Options [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options granted				2,275,745
Total number of shares outstanding				5,757,824	8,118,041
Stock-based compensation expense | $				$ 26,609,000	$ 47,695,000	54,971,000
Total unrecognized stock-based compensation expense | $				$ 24,100,000
Weighted average period of unrecognized compensation costs				3 years 2 months 4 days
Intrinsic value of options exercised | $				$ 100,000	$ 1,900,000	4,400,000
Stock options exercise price per share | $ / shares				$ 52.52	$ 76.02
Exercise price per share of the replacement options | $ / shares				$ 58.04
Performance-Based Stock Options [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense | $				$ 0	$ 0	$ 0
Performance Shares [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options granted				0	0	0
Total unrecognized stock-based compensation expense | $				$ 24,900,000
Number of shares outstanding and unvested stock options				455,000
Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock units granted				1,338,925
Stock-based compensation expense | $				$ 27,058,000	$ 24,424,000	$ 5,587,000
Outstanding and unvested restricted stock units				3,000,390	3,088,394
Performance restricted stock units vested				430,704
Restricted Stock Units Vest One Year Anniversary [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock units vesting percentage				25.00%
2011 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options granted				0
2014 Plan [Member] | Performance Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Fair value of restricted stock units vested | $				$ 1,400,000	$ 9,600,000
Stock-based compensation expense | $				$ 3,600,000	$ 14,300,000
Regulatory development Milestone achieved | Milestone					3
2014 Plan [Member] | Performance-Based Stock Options [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense | $					$ 10,700,000
Regulatory development Milestone achieved | Milestone				0	1	0
2016 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total number of shares reserved for issuance							428,074			1,200,000
2014 Employee Stock Purchase Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total number of shares reserved for issuance			1,082,000						300,000		282,000
Additional number of shares reserved for issuance			500,000
Common stock available for issuance under stock option plan				419,194
Number of shares issued under the plan				662,806
2024 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common stock shares annual increase added to plan	11,002,166
Total number of shares reserved for issuance	5,500,000
Common stock available for issuance under stock option plan				7,490,967
Option Exchange Program [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options granted		1,483,113
Share based compensation granted under plan vested period		18 months
Share based compensation, term of plan		7 years
Options to purchase		3,079,608
Exercise price per share of the replacement options | $ / shares		$ 22.2
Additional stock-based compensation expense | $				$ 1,700,000
Replacement options vesting period				18 months
Option Exchange Program [Member] | Minimum [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock options exercise price per share | $ / shares								$ 35
2024 Plan, 2014 Plan and 2016 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total number of shares outstanding				8,758,214