Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Total revenues	$ 41,243	$ 86,455	$ 7,686
Operating costs and expenses:
Cost of revenues	9,444	2,159	813
Research and development	225,895	356,235	326,163
Selling, general and administrative	216,420	274,524	227,699
Restructuring	21,854	33,386
Total operating costs and expenses	473,613	666,304	554,675
Loss from operations	(432,370)	(579,849)	(546,989)
Interest income, net	31,675	38,743	14,190
Other income (expense), net	29	(383)	15
Net loss	$ (400,666)	$ (541,489)	$ (532,784)
Net loss per share - basic	$ (6.59)	$ (9.05)	$ (8.98)
Net loss per share - diluted	$ (6.59)	$ (9.05)	$ (8.98)
Weighted average number of common shares outstanding—basic	60,765,913	59,836,441	59,306,094
Weighted average number of common shares outstanding—diluted	60,765,913	59,836,441	59,306,094
Comprehensive loss:
Net Income (Loss)	$ (400,666)	$ (541,489)	$ (532,784)
Other comprehensive items:
Unrealized gain (loss) on marketable securities	1,058	9,392	(7,546)
Total comprehensive loss	(399,608)	(532,097)	(540,330)
Product Revenue [Member]
Total revenues	3,574	10,454	$ 7,686
License And Milestone Revenue - Related Party [Member]
Total revenues		75,000
Collaboration Revenue - Related Party [Member]
Total revenues	36,087	824
Other Collaboration Revenue [Member]
Total revenues	$ 1,582	$ 177