Stock-Based Compensation - Additional Information (Detail)				3 Months Ended			6 Months Ended
	Jun. 10, 2024 shares	Feb. 21, 2024 $ / shares shares	Jun. 15, 2023 shares	Jun. 30, 2024 USD ($) $ / shares shares	Jun. 30, 2023 USD ($) shares	Mar. 31, 2023 USD ($) Milestone	Jun. 30, 2024 USD ($) Milestone $ / shares shares	Jun. 30, 2023 USD ($) Milestone $ / shares shares	Apr. 16, 2024 shares	Jan. 23, 2024 $ / shares	Dec. 31, 2023 $ / shares shares	Jun. 16, 2022 shares	Sep. 20, 2018 shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share based compensation granted under plan vested period							4 years
Share based compensation, vest period							1 year
Share based compensation, term of plan							10 years
Stock-based compensation expense tied to total stockholder return | $							$ 30,865,000	$ 31,731,000
Stock-based compensation expense | $				$ 17,167,000	$ 11,693,000		30,865,000	$ 31,731,000
Total unrecognized stock-based compensation expense | $				$ 40,300,000			$ 40,300,000
Weighted average grant date fair value per share | $ / shares							$ 14.69	$ 30.41
Time Based Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock units granted				24,941	0		882,025	330,617
Restricted stock units vested				10,096	14,144		80,039	28,577
Fair value of restricted stock units vested | $				$ 100,000	$ 700,000		$ 1,700,000	$ 1,300,000
Outstanding and unvested restricted stock units				2,343,027			2,343,027
Total unrecognized stock-based compensation expense | $				$ 28,800,000			$ 28,800,000
Performance Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense tied to total stockholder return | $				$ 400,000	$ 21,000		$ 800,000	$ 300,000
Restricted stock units granted				0	39,603		395,055	862,321
Fair value of restricted stock units vested | $				$ 0	$ 0		$ 0
Stock-based compensation expense | $				$ 2,800,000
Outstanding and unvested restricted stock units				1,769,892			1,769,892
Total unrecognized stock-based compensation expense | $				$ 66,500,000			$ 66,500,000
Stock Options [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options granted							2,162,855
Stock options exercise price per share | $ / shares				$ 54.99			$ 54.99				$ 76.02
Total number of shares outstanding				7,006,329			7,006,329				8,118,041
Stock-based compensation expense | $				$ 7,724,000	9,663,000		$ 15,175,000	$ 19,678,000
Weighted average period of unrecognized compensation costs							2 years 7 months 28 days
Intrinsic value of options exercised | $							$ 100,000	1,900,000
Exercise price per share of the replacement options | $ / shares				$ 66.73			$ 66.73
Options elected to be cancelled							3,243,941
Performance-Based Stock Options [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense | $					0		$ 0	$ 0
Performance Shares [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options granted							0	0
Total unrecognized stock-based compensation expense | $				$ 24,900,000			$ 24,900,000
Number of shares outstanding and unvested stock options				455,000			455,000
Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock units granted							1,277,080
Stock-based compensation expense | $				$ 9,223,000	$ 1,618,000		$ 14,942,000	$ 11,171,000
Outstanding and unvested restricted stock units				4,112,919			4,112,919				3,088,394
Restricted Stock Units Vest One Year Anniversary [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock units vesting percentage							25.00%
2011 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options granted							0
Total number of shares outstanding				0			0
2014 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options granted							0
2014 Plan [Member] | Performance Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Fair value of restricted stock units vested | $						$ 5,500,000
Stock-based compensation expense | $						$ 8,500,000
Regulatory development Milestone achieved | Milestone						1
2014 Plan [Member] | Performance-Based Stock Options [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Regulatory development Milestone achieved | Milestone							0	0
2016 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total number of shares reserved for issuance									428,074				1,200,000
2014 Employee Stock Purchase Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Additional number of shares reserved for issuance			500,000
Total number of shares reserved for issuance			1,082,000									300,000
Common stock available for issuance under stock option plan				574,678			574,678
Option Exchange Program [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options granted		1,483,113
Share based compensation granted under plan vested period		18 months
Share based compensation, term of plan		7 years
Exercise price per share of the replacement options | $ / shares		$ 22.2
Options to purchase		3,079,608
Additional stock-based compensation expense | $							$ 1,700,000
Replacement options vesting period							18 months
Option Exchange Program [Member] | Minimum [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock options exercise price per share | $ / shares										$ 35
2024 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common stock shares annual increase added to plan	11,002,166
Total number of shares reserved for issuance	5,500,000
Common stock available for issuance under stock option plan				5,480,598			5,480,598
2024 Plan, 2014 Plan and 2016 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total number of shares outstanding				11,119,248			11,119,248