Stock-Based Compensation - Additional Information (Detail)		12 Months Ended
	Jan. 01, 2023 shares	Dec. 31, 2023 USD ($) Milestone $ / shares shares	Dec. 31, 2022 USD ($) Milestone $ / shares shares	Dec. 31, 2021 USD ($) Milestone $ / shares shares	Jun. 16, 2023 shares	Jun. 16, 2022 shares	Sep. 20, 2018 shares	Jul. 02, 2014 shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share based compensation granted under plan vested period		4 years
Share based compensation, vest period		1 year
Share based compensation, term of plan		10 years
Total number of shares outstanding | shares		11,206,435
Common stock available for issuance under stock option plan | shares		7,407,863
Stock-based compensation expense | $		$ 73,367,000	$ 61,602,000	$ 104,629,000
Stock-based compensation expense tied to total stockholder return | $		$ 73,367,000	$ 61,602,000	$ 104,629,000
Weighted average grant date fair value per share | $ / shares		$ 29.53	$ 25.96	$ 51.87
Share option, weighted-average forfeiture rates		16.60%	19.20%	16.70%
Restructuring [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense | $		$ 838,000	$ 0	$ 0
Time Based Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock units vested | shares		51,851	366,014	113,941
Fair value of restricted stock units vested | $		$ 1,800,000	$ 12,400,000	$ 8,800,000
Outstanding and unvested restricted stock units | shares		1,662,363
Total unrecognized stock-based compensation expense | $		$ 40,200,000
Weighted average period of unrecognized compensation costs		1 year 8 months 15 days
Performance Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock units granted | shares		905,012	705,380	531,176
Fair value of restricted stock units vested | $			$ 0
Stock-based compensation expense | $		$ 0	$ 0	$ 0
Stock-based compensation expense tied to total stockholder return | $		$ 700,000
Outstanding and unvested restricted stock units | shares		1,426,031
Total unrecognized stock-based compensation expense | $		$ 65,800,000
Stock Options [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options granted | shares		964,253
Total number of shares outstanding | shares		8,118,041	7,788,350
Stock-based compensation expense | $		$ 47,695,000	$ 54,971,000	78,516,000
Total unrecognized stock-based compensation expense | $		$ 42,700,000
Weighted average period of unrecognized compensation costs		2 years 9 months 3 days
Intrinsic value of options exercised | $		$ 1,900,000	4,400,000	9,000,000
Performance-Based Stock Options [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense | $		$ 0	$ 0	$ 0
Performance Shares [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options granted | shares		0	0
Total unrecognized stock-based compensation expense | $		$ 24,900,000
Number of shares outstanding and unvested stock options | shares		455,000
Performance Shares [Member] | Chief Executive Officer [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options granted | shares				650,000
Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock units granted | shares		2,639,729
Stock-based compensation expense | $		$ 24,424,000	$ 5,587,000	$ 25,375,000
Outstanding and unvested restricted stock units | shares		3,088,394	1,415,481
Restricted Stock Units Vest One Year Anniversary [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock units vesting percentage		25.00%
2011 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options granted | shares		0
2014 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common stock shares annual increase added to plan | shares	2,380,365
2014 Plan [Member] | Performance Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Fair value of restricted stock units vested | $		$ 9,600,000		9,500,000
Stock-based compensation expense | $		$ 14,300,000		$ 16,600,000
Regulatory development Milestone achieved | Milestone		3		2
2014 Plan [Member] | Performance-Based Stock Options [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense | $		$ 10,700,000
Regulatory development Milestone achieved | Milestone		1	0	0
2014 Plan [Member] | Maximum [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of increase on outstanding shares of Common stock			4.00%
2016 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total number of shares reserved for issuance | shares							1,200,000
2014 Employee Stock Purchase Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total number of shares reserved for issuance | shares					500,000	300,000		282,000
Number of shares issued under the plan | shares		445,920
Accrued expenses | $		$ 400,000
Total number of shares available for issuance | shares		636,080