Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Total revenue	$ 86,455	$ 7,686	$ 6,308
Operating costs and expenses:
Cost of revenues	2,159	813	553
Research and development	356,235	326,163	283,166
Selling, general and administrative	274,524	227,699	183,498
Restructuring	33,386
Total operating costs and expenses	666,304	554,675	467,217
Loss from operations	(579,849)	(546,989)	(460,909)
Interest income, net	38,743	14,190	2,883
Other income (expense), net	(383)	15	134
Net loss	$ (541,489)	$ (532,784)	$ (457,892)
Net loss per share - basic	$ (9.05)	$ (8.98)	$ (7.8)
Net loss per share - diluted	$ (9.05)	$ (8.98)	$ (7.8)
Weighted average number of common shares outstanding—basic	59,836,441	59,306,094	58,670,230
Weighted average number of common shares outstanding—diluted	59,836,441	59,306,094	58,670,230
Comprehensive loss:
Net Income (Loss)	$ (541,489)	$ (532,784)	$ (457,892)
Other comprehensive items:
Unrealized gain (loss) on marketable securities	9,392	(7,546)	(3,075)
Total comprehensive loss	(532,097)	(540,330)	(460,967)
Product Revenue [Member]
Total revenue	10,454	$ 7,686	$ 6,308
License And Milestone Revenue - Related Party [Member]
Total revenue	75,000
Collaboration Revenue - Related Party [Member]
Total revenue	824
Other Collaboration Revenue [Member]
Total revenue	$ 177