Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Total revenue	$ 2,474	$ 1,501	$ 5,768	$ 3,082
Operating costs and expenses:
Cost of goods sold	205	200	435	486
Research and development	97,161	77,297	189,987	155,315
Selling, general and administrative	75,565	52,411	141,273	98,888
Total operating costs and expenses	172,931	129,908	331,695	254,689
Loss from operations	(170,457)	(128,407)	(325,927)	(251,607)
Interest income, net	10,173	2,102	19,003	3,270
Other income (expense), net	(41)	45	(229)	22
Net loss	$ (160,325)	$ (126,260)	$ (307,153)	$ (248,315)
Net loss per share—basic	$ (2.68)	$ (2.13)	$ (5.14)	$ (4.2)
Net loss per share—diluted	$ (2.68)	$ (2.13)	$ (5.14)	$ (4.2)
Weighted average number of common shares outstanding— basic	59,769,640	59,266,322	59,722,147	59,148,246
Weighted average number of common shares outstanding— diluted	59,769,640	59,266,322	59,722,147	59,148,246
Comprehensive loss:
Net loss	$ (160,325)	$ (126,260)	$ (307,153)	$ (248,315)
Other comprehensive items:
Unrealized gain (loss) on marketable securities	(556)	(2,671)	4,562	(11,212)
Total other comprehensive gain (loss)	(556)	(2,671)	4,562	(11,212)
Total comprehensive loss	(160,881)	(128,931)	(302,591)	(259,527)
Product Revenue [Member]
Total revenue	2,460	$ 1,501	5,754	$ 3,082
Collaboration Revenue [Member]
Total revenue	$ 14		$ 14