Condensed Consolidated Statements of Changes in Stockholders' Equity (Unaudited) - USD ($) $ in Thousands	Total	Common Stock [Member]	Treasury Stock [Member]	Additional Paid-in Capital [Member]	Accumulated Other Comprehensive Loss [Member]	Accumulated Deficit [Member]
Balances at Dec. 31, 2021	$ 1,729,031	$ 6	$ (400)	$ 3,227,471	$ (2,660)	$ (1,495,386)
Balances, Shares at Dec. 31, 2021		58,937,050	3,033
Issuance of common stock from exercises of stock options, Amount	646			646
Issuance of common stock from exercises of stock options, Shares		105,474
Issuance of common stock under the employee stock purchase plan	1,153			1,153
Issuance of common stock under the employee stock purchase plan, Shares		23,625
Stock-based compensation expense	18,268			18,268
Change in unrealized loss on available-for-sale securities	(8,541)				(8,541)
Net loss	(122,055)					(122,055)
Balances at Mar. 31, 2022	1,618,502	$ 6	$ (400)	3,247,538	(11,201)	(1,617,441)
Balance, Shares at Mar. 31, 2022		59,066,149	3,033
Balances at Dec. 31, 2022	1,252,599	$ 6	$ (400)	3,291,369	(10,206)	(2,028,170)
Balances, Shares at Dec. 31, 2022		59,509,125	3,033
Issuance of common stock from exercises of stock options, Amount	438			438
Issuance of common stock from exercises of stock options, Shares		52,058
Issuance of common stock under the employee stock purchase plan	2,863			2,863
Issuance of common stock under the employee stock purchase plan, Shares		76,105
Stock-based compensation expense	19,568			19,568
Change in unrealized loss on available-for-sale securities	5,118				5,118
Vesting of restricted stock units, net of employee tax obligations	(629)			(629)
Vesting of restricted stock units, net of employee tax obligations, Shares		124,713
Net loss	(146,828)					(146,828)
Balances at Mar. 31, 2023	$ 1,133,129	$ 6	$ (400)	$ 3,313,609	$ (5,088)	$ (2,174,998)
Balance, Shares at Mar. 31, 2023		59,762,001	3,033