Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Current assets:
Cash and cash equivalents	$ 206,557	$ 162,700
Marketable securities	923,028	1,109,794
Prepaid expenses and other current assets	58,850	50,826
Collaboration receivable - related party	15,002	13,660
Total current assets	1,203,437	1,336,980
Property and equipment, net	2,663	2,898
Restricted cash	1,269	1,269
Right-of-use operating asset	9,062	10,532
Other long-term assets	4,255	4,770
Total assets	1,220,686	1,356,449
Current liabilities:
Accounts payable	12,263	18,950
Accrued expenses	64,745	72,666
Operating lease liability, current portion	7,684	7,643
Total current liabilities	84,692	99,259
Operating lease liability, net of current portion	2,763	4,491
Other liabilities	102	100
Total liabilities	87,557	103,850
Commitments and contingencies (Note 5)
Stockholders’ equity:
Preferred stock, $0.0001 par value per share; 5,000,000 shares authorized at March 31, 2023 and December 31, 2022; no shares issued or outstanding at March 31, 2023 and December 31, 2022
Common stock, $0.0001 par value per share; 120,000,000 shares authorized at March 31, 2023 and December 31, 2022; 59,765,034 and 59,512,158 shares issued at March 31, 2023 and December 31, 2022; 59,762,001 and 59,509,125 shares outstanding at March 31, 2023 and December 31, 2022	6	6
Treasury stock, at cost, 3,033 shares at March 31, 2023 and December 31, 2022	(400)	(400)
Additional paid-in capital	3,313,609	3,291,369
Accumulated deficit	(2,174,998)	(2,028,170)
Accumulated other comprehensive loss	(5,088)	(10,206)
Total stockholders’ equity	1,133,129	1,252,599
Total liabilities and stockholders’ equity	$ 1,220,686	$ 1,356,449