Stock-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2023

Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]

Summary of Activity Relating to Restricted Stock Units

The following table summarizes activity relating to time-based restricted stock units and performance restricted stock units:

	Shares			Weighted Average Grant Date Fair Value
Outstanding as of December 31, 2022		1,415,481		$	48.73
Granted		1,153,335			42.78
Vested		(138,923	)		67.47
Forfeited		(20,037	)		48.18
Outstanding as of March 31, 2023		2,409,856			44.81

Summary of Activity Relating to Time Based and Performance Based Stock Options

The following table summarizes activity related to time-based and performance-based stock options:

	Shares			Weighted Average Exercise Price		Weighted Average Remaining Life (in years)		Aggregate Intrinsic Value (in thousands)
Outstanding as of December 31, 2022		7,788,350		$	77.95		6.36	$	7,275
Granted		712,041		$	44.58
Exercised		(45,908	)	$	5.45
Forfeited		(71,173	)	$	96.42
Outstanding as of March 31, 2023		8,383,310		$	75.36		6.46	$	12,177
Exercisable as of March 31, 2023		5,318,637		$	84.92		5.19	$	8,365

Summary of Stock-Based Compensation Expense Recognized

The following table summarizes stock-based compensation expense recognized during the three months ended March 31, 2023:

	Three Months Ended March 31,
	2023		2022
	(in thousands)
Research and development	$	8,773	$	8,615
Selling, general and administrative		11,265		9,938
	$	20,038	$	18,553

Summary of Stock-Based Compensation Expense by Award Type

The following table summarizes stock-based compensation expense by award type recognized during the three months ended March 31, 2023:

	Three Months Ended March 31,
	2023		2022
	(in thousands)
Stock options	$	10,015	$	15,465
Restricted stock units		9,553		2,803
Employee stock purchase plan		470		285
	$	20,038	$	18,553