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Stock-Based Compensation - Summary of Activity Relating to Time Based and Performance Based Stock Options (Detail) - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Ending balance, Outstanding Shares 9,203,831  
Stock Options [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Beginning balance, Outstanding Shares 7,283,439  
Granted, Shares 1,181,487  
Exercised, Shares (156,195)  
Forfeited, Shares (520,381)  
Ending balance, Outstanding Shares 7,788,350 7,283,439
Vested and expected to vest, Shares 6,724,505  
Exercisable, Shares 5,109,027  
Beginning balance, Outstanding Weighted Average Exercise Price $ 84.17  
Granted, Weighted Average Exercise Price 39.45  
Exercised, Weighted Average Exercise Price 7.84  
Forfeited, Weighted Average Exercise Price 98.65  
Ending balance, Outstanding Weighted Average Exercise Price 77.95 $ 84.17
Vested and expected to vest, Weighted Average Exercise Price 78.86  
Exercisable, Weighted Average Exercise Price $ 85.76  
Outstanding, Weighted Average Remaining Life 6 years 4 months 9 days 6 years 8 months 26 days
Vested and expected to vest, Weighted Average Remaining Life 6 years 18 days  
Exercisable, Weighted Average Remaining Life 5 years 2 months 19 days  
Outstanding, Aggregate Intrinsic Value $ 7,275 $ 16,590
Vested and expected to vest, Aggregate Intrinsic Value 6,917  
Exercisable, Aggregate Intrinsic Value $ 5,607