Consolidated Statements of Operations and Comprehensive Income (Loss) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Total revenue	$ 7,686	$ 6,308	$ 1,114,200
Operating costs and expenses:
Cost of goods sold	813	553	565
Research and development	326,163	283,166	292,714
Selling, general and administrative	227,699	183,498	196,952
Restructuring			27,743
Total operating costs and expenses	554,675	467,217	517,974
Income (loss) from operations	(546,989)	(460,909)	596,226
Interest income, net	14,190	2,883	9,597
Other income, net	15	134	250
Net income (loss)	$ (532,784)	$ (457,892)	$ 606,073
Net income (loss) per share—basic	$ (8.98)	$ (7.80)	$ 11.66
Net income (loss) per share—diluted	$ (8.98)	$ (7.80)	$ 11.43
Weighted average number of common shares outstanding—basic	59,306,094	58,670,230	51,983,188
Weighted average number of common shares outstanding—diluted	59,306,094	58,670,230	53,003,115
Comprehensive income (loss):
Net income (loss)	$ (532,784)	$ (457,892)	$ 606,073
Other comprehensive items:
Unrealized loss on marketable securities	(7,546)	(3,075)	(880)
Total other comprehensive loss	(7,546)	(3,075)	(880)
Total comprehensive income (loss)	(540,330)	(460,967)	605,193
Product Revenue [Member]
Total revenue	$ 7,686	$ 6,308	6,700
Collaboration Revenue - Related Party [Member]
Total revenue			$ 1,107,500