Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 162,700	$ 294,233
Marketable securities	1,109,794	1,448,063
Prepaid expenses and other current assets	50,826	39,841
Collaboration receivable - related party	13,660	18,506
Total current assets	1,336,980	1,800,643
Property and equipment, net	2,898	3,016
Restricted cash	1,269	1,269
Right-of-use operating asset	10,532	16,109
Other long-term assets	4,770	4,251
Total assets	1,356,449	1,825,288
Current liabilities:
Accounts payable	18,950	10,450
Accrued expenses	72,666	67,275
Operating lease liability, current portion	7,643	7,468
Total current liabilities	99,259	85,193
Operating lease liability, net of current portion	4,491	10,964
Other liabilities	100	100
Total liabilities	103,850	96,257
Commitments and contingencies (Note 5)
Stockholders’ equity:
Preferred stock, $0.0001 par value per share; 5,000,000 shares authorized at December 31, 2022 and December 31, 2021; no shares issued or outstanding at December 31, 2022 and December 31, 2021
Common stock, $0.0001 par value per share; 120,000,000 shares authorized at December 31, 2022 and December 31, 2021; 59,512,158 and 58,940,083 shares issued at December 31, 2022 and December 31, 2021; 59,509,125 and 58,937,050 shares outstanding at December 31, 2022 and December 31, 2021	6	6
Treasury stock, at cost, 3,033 shares at December 31, 2022 and December 31, 2021	(400)	(400)
Additional paid-in capital	3,291,369	3,227,471
Accumulated deficit	(2,028,170)	(1,495,386)
Accumulated other comprehensive loss	(10,206)	(2,660)
Total stockholders’ equity	1,252,599	1,729,031
Total liabilities and stockholders’ equity	$ 1,356,449	$ 1,825,288